5-(3-benzoylthiopropyn-1-yl)-2'-deoxyuridine 3',5'-di-tert-butyldimethylsilyl ether

Base Information

Chemical Name:5-(3-benzoylthiopropyn-1-yl)-2'-deoxyuridine 3',5'-di-tert-butyldimethylsilyl ether
CAS No.:172531-41-8
Molecular Formula:C₃₁H₄₆N₂O₆SSi₂
Molecular Weight:630.953
Hs Code.:

Synonyms:5-(3-benzoylthiopropyn-1-yl)-2'-deoxyuridine 3',5'-di-tert-butyldimethylsilyl ether

Suppliers and Price of 5-(3-benzoylthiopropyn-1-yl)-2'-deoxyuridine 3',5'-di-tert-butyldimethylsilyl ether

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Chemical Property of 5-(3-benzoylthiopropyn-1-yl)-2'-deoxyuridine 3',5'-di-tert-butyldimethylsilyl ether

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Technology Process of 5-(3-benzoylthiopropyn-1-yl)-2'-deoxyuridine 3',5'-di-tert-butyldimethylsilyl ether

There total 4 articles about 5-(3-benzoylthiopropyn-1-yl)-2'-deoxyuridine 3',5'-di-tert-butyldimethylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54-42-2,162239-35-2
5-Iodo-2'-deoxyuridine

: 172531-41-8
5-(3-benzoylthiopropyn-1-yl)-2'-deoxyuridine 3',5'-di-tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / imidazole / dimethylformamide / 2 h / 23 °C

2: 67 percent / Et₃N, Pd(PPh₃)4, CuI / dimethylformamide / 2 h / 23 °C

3: 1.) MsCl, Et₃N / 1.) CH₂Cl₂, -50 deg C, 40 min, 2.) CH₂Cl₂, from -50 deg C to RT, 3 h

With 1H-imidazole; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonyl chloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/ja00147a004

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 172531-41-8
5-(3-benzoylthiopropyn-1-yl)-2'-deoxyuridine 3',5'-di-tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / imidazole / dimethylformamide / 2 h / 23 °C

2: 67 percent / Et₃N, Pd(PPh₃)4, CuI / dimethylformamide / 2 h / 23 °C

3: 1.) MsCl, Et₃N / 1.) CH₂Cl₂, -50 deg C, 40 min, 2.) CH₂Cl₂, from -50 deg C to RT, 3 h

With 1H-imidazole; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonyl chloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/ja00147a004

Reference yield:

: 148134-86-5
2'-deoxy-3',5'-bis(O-tert-butyldimethylsilyl)-5-iodouridine

: 172531-41-8
5-(3-benzoylthiopropyn-1-yl)-2'-deoxyuridine 3',5'-di-tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / Et₃N, Pd(PPh₃)4, CuI / dimethylformamide / 2 h / 23 °C

2: 1.) MsCl, Et₃N / 1.) CH₂Cl₂, -50 deg C, 40 min, 2.) CH₂Cl₂, from -50 deg C to RT, 3 h

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonyl chloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/ja00147a004