4-[(3S,4S)-3-tertiary butoxycarbonylamino-4-fluoromethyl-1-pyrrolidinyl]-2,5-difluoro-3-methyl-benzoic acid

Base Information

Chemical Name:4-[(3S,4S)-3-tertiary butoxycarbonylamino-4-fluoromethyl-1-pyrrolidinyl]-2,5-difluoro-3-methyl-benzoic acid
CAS No.:902473-29-4
Molecular Formula:C₁₈H₂₃F₃N₂O₄
Molecular Weight:388.387
Hs Code.:

Synonyms:4-[(3S,4S)-3-tertiary butoxycarbonylamino-4-fluoromethyl-1-pyrrolidinyl]-2,5-difluoro-3-methyl-benzoic acid

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Chemical Property of 4-[(3S,4S)-3-tertiary butoxycarbonylamino-4-fluoromethyl-1-pyrrolidinyl]-2,5-difluoro-3-methyl-benzoic acid

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Technology Process of 4-[(3S,4S)-3-tertiary butoxycarbonylamino-4-fluoromethyl-1-pyrrolidinyl]-2,5-difluoro-3-methyl-benzoic acid

There total 1 articles about 4-[(3S,4S)-3-tertiary butoxycarbonylamino-4-fluoromethyl-1-pyrrolidinyl]-2,5-difluoro-3-methyl-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 902473-24-9
ethyl 4-[(3S,4S)-3-tertiary butoxycarbonylamino-4-fluoromethyl-1-pyrrolidinyl]-2,5-difluoro-3-methylbenzoate

: 902473-29-4
4-[(3S,4S)-3-tertiary butoxycarbonylamino-4-fluoromethyl-1-pyrrolidinyl]-2,5-difluoro-3-methyl-benzoic acid

Guidance literature:: ethyl 4-[(3S,4S)-3-tertiary butoxycarbonylamino-4-fluoromethyl-1-pyrrolidinyl]-2,5-difluoro-3-methylbenzoate; With potassium hydroxide; water; at 20 ℃; for 1h;

With citric acid; In water; pH=2 - 3;

Reference yield:

: 902473-29-4
4-[(3S,4S)-3-tertiary butoxycarbonylamino-4-fluoromethyl-1-pyrrolidinyl]-2,5-difluoro-3-methyl-benzoic acid

: 902473-25-0
ethyl 4-[(3S,4S)-3-tertiary butoxycarbonylamino-4-fluoromethyl-1-pyrrolidinyl]-2,5-difluoro-3-methylbenzoylacetate

Guidance literature:: hydrogen ethyl malonate; With magnesium ethylate; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

4-[(3S,4S)-3-tertiary butoxycarbonylamino-4-fluoromethyl-1-pyrrolidinyl]-2,5-difluoro-3-methyl-benzoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

With citric acid; In tetrahydrofuran; water; toluene; pH=2 - 3;