(R)-tert-butyl 2-(benzyloxy)-1-(3-iodo-4,5-dimethoxyphenyl)ethylcarbamate

Base Information

Chemical Name:(R)-tert-butyl 2-(benzyloxy)-1-(3-iodo-4,5-dimethoxyphenyl)ethylcarbamate
CAS No.:1195785-22-8
Molecular Formula:C₂₂H₂₈INO₅
Molecular Weight:513.373
Hs Code.:

Synonyms:(R)-tert-butyl 2-(benzyloxy)-1-(3-iodo-4,5-dimethoxyphenyl)ethylcarbamate

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Chemical Property of (R)-tert-butyl 2-(benzyloxy)-1-(3-iodo-4,5-dimethoxyphenyl)ethylcarbamate

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Technology Process of (R)-tert-butyl 2-(benzyloxy)-1-(3-iodo-4,5-dimethoxyphenyl)ethylcarbamate

There total 1 articles about (R)-tert-butyl 2-(benzyloxy)-1-(3-iodo-4,5-dimethoxyphenyl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1195785-20-6
(R)-tert-butyl 2-hydroxy-1-(3-iodo-4,5-dimethoxyphenyl)ethylcarbamate

: 100-39-0
benzyl bromide

: 1195785-22-8
(R)-tert-butyl 2-(benzyloxy)-1-(3-iodo-4,5-dimethoxyphenyl)ethylcarbamate

Guidance literature:: (R)-tert-butyl 2-hydroxy-1-(3-iodo-4,5-dimethoxyphenyl)ethylcarbamate; With sodium hydride; In N,N-dimethyl-formamide; at -5 ℃; for 0.333333h;

benzyl bromide; In N,N-dimethyl-formamide;
DOI:10.1021/ja907193b

Reference yield:

: 121-43-7,63156-11-6
Trimethyl borate

: 1195785-22-8
(R)-tert-butyl 2-(benzyloxy)-1-(3-iodo-4,5-dimethoxyphenyl)ethylcarbamate

: C₂₄H₃₄BNO₇

Guidance literature:: (R)-tert-butyl 2-(benzyloxy)-1-(3-iodo-4,5-dimethoxyphenyl)ethylcarbamate; With isopropylmagnesium chloride; In tetrahydrofuran; at 0 ℃;

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;

Trimethyl borate; In tetrahydrofuran; hexane; at -78 - 23 ℃;
DOI:10.1021/ja907193b

Reference yield:

: 1195785-22-8
(R)-tert-butyl 2-(benzyloxy)-1-(3-iodo-4,5-dimethoxyphenyl)ethylcarbamate

: 1420010-03-2
C₃₀H₃₅BrN₂O₆

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

1.3: 18 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride / tetrahydrofuran; water / 0.5 h / pH 3 / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,2-dimethoxyethane / 24 h / 80 °C / Inert atmosphere

4.1: dmap / dichloromethane / 16 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; isopropylmagnesium chloride; sodium hydrogencarbonate; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 3.1: |Suzuki Coupling;
DOI:10.1021/ja3121394