(2S,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-methoxymethyl-2-methylpentanoic acid

Base Information

Chemical Name:(2S,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-methoxymethyl-2-methylpentanoic acid
CAS No.:1562404-68-5
Molecular Formula:C₂₆H₂₇ClFN₃O₅
Molecular Weight:515.969
Hs Code.:

Synonyms:(2S,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-methoxymethyl-2-methylpentanoic acid

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Chemical Property of (2S,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-methoxymethyl-2-methylpentanoic acid

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Technology Process of (2S,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-methoxymethyl-2-methylpentanoic acid

There total 12 articles about (2S,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-methoxymethyl-2-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1562405-23-5
C₂₈H₃₁ClFN₃O₅

: 1562404-68-5
(2S,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-methoxymethyl-2-methylpentanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 60 ℃; for 3h;

Reference yield:

: 1562404-86-7
(2S,4R)-4-t-butoxycarbonylamino-5-(5’-chloro-2’-fluorobiphenyl-4-yl)-2-hydroxymethyl-2-methylpentanoic acid ethyl ester

: 1562404-68-5
(2S,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-methoxymethyl-2-methylpentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / Sealed tube

2.1: hydrogenchloride / 1,4-dioxane; acetonitrile / 0.17 h

3.1: HATU / N,N-dimethyl-formamide / 0.08 h

3.2: 0.33 h

4.1: sodium hydroxide / tetrahydrofuran / 3 h / 60 °C

With hydrogenchloride; tetra(n-butyl)ammonium hydrogensulfate; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1562405-00-8
(2S,4R)-4-amino-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-2-methylpentanoic acid ethyl ester

: 1562404-68-5
(2S,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-methoxymethyl-2-methylpentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; dmap / dichloromethane / 3 h

2.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / Sealed tube

3.1: hydrogenchloride / 1,4-dioxane; acetonitrile / 0.17 h

4.1: HATU / N,N-dimethyl-formamide / 0.08 h

4.2: 0.33 h

5.1: sodium hydroxide / tetrahydrofuran / 3 h / 60 °C

With hydrogenchloride; dmap; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;