BUTANEDIOIC ACID, 2-HYDROXY-3-METHYL-, DIETHYL ESTER

Base Information

• Chemical Name: BUTANEDIOIC ACID, 2-HYDROXY-3-METHYL-, DIETHYL ESTER
• CAS No.: 93504-92-8
• Molecular Formula: C9H16 O5
• Molecular Weight: 204.223
• Hs Code.: 2918199090
• Mol file: 93504-92-8.mol

Synonyms:Butanedioicacid, 2-hydroxy-3-methyl-, diethyl ester (9CI); Malic acid, 3-methyl-, diethylester (7CI)

Chemical Property of BUTANEDIOIC ACID, 2-HYDROXY-3-METHYL-, DIETHYL ESTER

Chemical Property:

• PSA: 72.83000
• LogP: 0.10960
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

≥99% ^*data from raw suppliers

Diethyl2-Hydroxy-3-methylbutanedioate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Diethyl 2-Hydroxy-3-methylbutanedioate is an intermediate used in the synthesis of 5-Methyl-2’-deoxy Cytidine-13C,15N2 (M295904), which is an isotopic analog of 5-Methyl-2’-deoxy Cytidine (M295900), a Cytidine (C998300) analog and also an isostere of Thymidine (T412000).

Technology Process of BUTANEDIOIC ACID, 2-HYDROXY-3-METHYL-, DIETHYL ESTER

There total 5 articles about BUTANEDIOIC ACID, 2-HYDROXY-3-METHYL-, DIETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl oxalpropionate (759-65-9) → 2-hydroxy-3-methylbutanedioic acid diethyl ester (93504-92-8)

Guidance literature:

With diethyl ether; aluminium amalgam;

Reference yield:

4,5-dioxo-tetrahydro-furan-3-carboxylic acid ethyl ester (86387-69-1) → 2-hydroxy-3-methylbutanedioic acid diethyl ester (93504-92-8)

Guidance literature:

With ethanol; nickel; at 100 ℃; under 73550.8 Torr; Hydrogenation;

Reference yield:

4,5-dioxo-tetrahydro-furan-3-carboxylic acid ethyl ester (86387-69-1) + ethanol (64-17-5) → 2-hydroxy-3-methyl-succinic acid-4-ethyl ester + 2-hydroxy-3-methylbutanedioic acid diethyl ester (93504-92-8)

Guidance literature:

at 100 ℃; under 73550.8 Torr; Hydrogenation;

upstream raw materials:

4,5-dioxo-tetrahydro-furan-3-carboxylic acid ethyl ester

diethyl oxalpropionate

ethanol

Downstream raw materials:

2,4-dihydroxy-5-methylpyrimidine

dimethyl 2-hydroxy-3-methylbutane-1,4-dioate

dimethyl 2-hydroxy-3-methylbutane-1,4-dioate

(2S,3S)-2-Hydroxy-3-methyl-succinic acid

Refernces