(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (R)-3-(N-isopropyl-N-benzylamino)butanamide

Base Information

Chemical Name:(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (R)-3-(N-isopropyl-N-benzylamino)butanamide
CAS No.:1330630-61-9
Molecular Formula:C₃₀H₄₀N₂O₂
Molecular Weight:460.66
Hs Code.:

Synonyms:(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (R)-3-(N-isopropyl-N-benzylamino)butanamide

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Chemical Property of (S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (R)-3-(N-isopropyl-N-benzylamino)butanamide

Chemical Property:

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Technology Process of (S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (R)-3-(N-isopropyl-N-benzylamino)butanamide

There total 6 articles about (S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (R)-3-(N-isopropyl-N-benzylamino)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1330630-57-3
(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (E)-but-2-enamide

: 102-97-6
Benzyl-isopropyl-amin

: (S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (S)-3-(N-isopropyl-N-benzylamino)butanamide

: 1330630-61-9
(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (R)-3-(N-isopropyl-N-benzylamino)butanamide

Guidance literature:: Benzyl-isopropyl-amin; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 0.5h; Inert atmosphere;

(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (E)-but-2-enamide; In tetrahydrofuran; hexanes; at -78 ℃; for 2h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2011.05.102

Reference yield:

: 1177266-31-7
(S)-N-1-(1'-naphthyl)ethyl-O-tert-butylhydroxylamine (+)-camphorsulfonic acid salt

: C₁₄H₂₀ClNO

: 1330630-61-9
(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (R)-3-(N-isopropyl-N-benzylamino)butanamide

Guidance literature:: With potassium carbonate; In dichloromethane; Inert atmosphere;
DOI:10.1016/j.tet.2011.05.102

Reference yield:

: 1330630-75-5
tert-butyl (R)-3-(N-isopropylamino)butanoate

: 1330630-61-9
(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (R)-3-(N-isopropyl-N-benzylamino)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / 7 h / 100 °C

2.1: trifluoroacetic acid / dichloromethane / 2.08 h / 0 - 20 °C

2.2: Saturated solution

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

4.1: potassium carbonate / dichloromethane / Inert atmosphere

With oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.tet.2011.05.102