6-Chloro-1,7-naphthyridin-2(1H)-one

Base Information

Chemical Name:6-Chloro-1,7-naphthyridin-2(1H)-one
CAS No.:93493-68-6
Molecular Formula:C₈H₅ClN₂O
Molecular Weight:180.593
Hs Code.:2933990090
DSSTox Substance ID:DTXSID30575352
Nikkaji Number:J329.296G
Wikidata:Q82464686
Mol file:93493-68-6.mol

Synonyms:6-CHLORO-1,7-NAPHTHYRIDIN-2(1H)-ONE;93493-68-6;6-chloro-1H-1,7-naphthyridin-2-one;6-Chloro-1,7-naphthyridin-2-ol;MFCD08234986;1,7-Naphthyridin-2(1H)-one, 6-chloro-;1,7-Naphthyridin-2(1H)-one,6-chloro-;6-chloro-1,2-dihydro-1,7-naphthyridin-2-one;SCHEMBL707460;SCHEMBL24165631;DTXSID30575352;NRUPILJTHVRVPJ-UHFFFAOYSA-N;6-chloro-1,7-naphthyridin-2-one;6-chloro-1,7-naphthyridine-2-one;AMY27696;ZB0761;AKOS006284252;SY128421;CS-0134060;EN300-113197;A844614

Suppliers and Price of 6-Chloro-1,7-naphthyridin-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-chloro-1,7-naphthyridin-2(1H)-one
50mg
$ 330.00

Matrix Scientific
6-Chloro-1,7-naphthyridin-2(1H)-one
5g
$ 2250.00

Matrix Scientific
6-Chloro-1,7-naphthyridin-2(1H)-one
500mg
$ 450.00

Matrix Scientific
6-Chloro-1,7-naphthyridin-2(1H)-one
1g
$ 750.00

Crysdot
6-Chloro-1,7-naphthyridin-2(1H)-one 95+%
1g
$ 680.00

American Custom Chemicals Corporation
6-CHLORO-1,7-NAPHTHYRIDIN-2(1H)-ONE 95.00%
5MG
$ 501.48

Alichem
6-Chloro-1,7-naphthyridin-2(1H)-one
25g
$ 5173.74

Alichem
6-Chloro-1,7-naphthyridin-2(1H)-one
10g
$ 2954.70

Alichem
6-Chloro-1,7-naphthyridin-2(1H)-one
5g
$ 2130.60

AK Scientific
6-Chloro-1,7-naphthyridin-2(1H)-one
1g
$ 1680.00

Total 15 raw suppliers

Chemical Property of 6-Chloro-1,7-naphthyridin-2(1H)-one

Chemical Property:

Melting Point:304-306 °C
Boiling Point:425.9±45.0 °C(Predicted)
PKA:10.18±0.20(Predicted)
PSA：45.75000
Density:1.419±0.06 g/cm3(Predicted)
LogP:1.57650
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:180.0090405
Heavy Atom Count:12
Complexity:229

Purity/Quality:

97% ^*data from raw suppliers

6-chloro-1,7-naphthyridin-2(1H)-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=O)NC2=CN=C(C=C21)Cl

Technology Process of 6-Chloro-1,7-naphthyridin-2(1H)-one

There total 8 articles about 6-Chloro-1,7-naphthyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 93493-67-5
2-Chloro-5-<(2,2-dimethyl-1-oxopropyl)amino>-β-hydroxy-4-pyridinepropanoic Acid, 1,1-Dimethylethyl Ester

: 93493-68-6
6-Chloro-1,7-naphthyridin-2-one

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; for 4h; Heating;
DOI:10.1021/jo00302a049

Reference yield:

: ethyl 3-(2-chloro-5-nitro-4-pyridyl)-2-hydroxypropanoate

: 93493-68-6
6-Chloro-1,7-naphthyridin-2-one

Guidance literature:: ethyl 3-(2-chloro-5-nitro-4-pyridyl)-2-hydroxypropanoate; With iron; acetic acid; at 70 ℃; for 0.5h;

With hydrogenchloride; In 1,4-dioxane; at 70 - 90 ℃; for 4h;

Reference yield:

: 5350-93-6
6-Chloro-pyridin-3-ylamine

: 93493-68-6
6-Chloro-1,7-naphthyridin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

2: 1) tert-butyllithium / 1) THF, -78 deg C, 1.5 h; 2) THF, -78 deg C, 30 min

3: 65 percent / tetrahydrofuran / 0.5 h / -78 °C

4: 93 percent / 3N-aq. HCl / dioxane; H₂O / 4 h / Heating

With hydrogenchloride; tert.-butyl lithium; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jo00302a049