N-(6-chloro-4-formylpyridin-3-yl)pivalamide

Base Information

Chemical Name:N-(6-chloro-4-formylpyridin-3-yl)pivalamide
CAS No.:93493-66-4
Molecular Formula:C11H13ClN2O2
Molecular Weight:240.689
Hs Code.:
DSSTox Substance ID:DTXSID001197656
Nikkaji Number:J329.295I

Synonyms:93493-66-4;N-(6-chloro-4-formylpyridin-3-yl)pivalamide;Propanamide, N-(6-chloro-4-formyl-3-pyridinyl)-2,2-dimethyl-;SCHEMBL9649;NFPXRZAYLJWZRR-UHFFFAOYSA-N;DTXSID001197656;N-(6-Chloro-4-formyl-3-pyridinyl)-2,2-dimethylpropanamide;N-(6-chloro-4-formylpyridin-3-yl)-2,2-dimethylpropanamide;2,2-dimethyl-N-(2-chloro-4 -formyl-5-pyridinyl)propanamide

Suppliers and Price of N-(6-chloro-4-formylpyridin-3-yl)pivalamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(6-chloro-4-formylpyridin-3-yl)pivalamide

Chemical Property:

Melting Point:105-106.5 °C(Solv: hexane (110-54-3))
Boiling Point:416.2±45.0 °C(Predicted)
PSA：59.06000
Density:1.273±0.06 g/cm3(Predicted)
LogP:2.60510
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:240.0665554
Heavy Atom Count:16
Complexity:276

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)C(=O)NC1=CN=C(C=C1C=O)Cl

Technology Process of N-(6-chloro-4-formylpyridin-3-yl)pivalamide

There total 6 articles about N-(6-chloro-4-formylpyridin-3-yl)pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 93493-65-3
N-(6-Chloro-3-pyridinyl)-2,2-dimethylpropanamide

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 93493-66-4
N-(6-Chloro-4-formyl-3-pyridinyl)-2,2-dimethylpropanamide

Guidance literature:: N-(6-Chloro-3-pyridinyl)-2,2-dimethylpropanamide; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 1h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; for 1h;

With water; ammonium chloride; In tetrahydrofuran; at -78 ℃;

Reference yield:

: 124-38-9,18923-20-1
carbon dioxide

: 93493-65-3
N-(6-Chloro-3-pyridinyl)-2,2-dimethylpropanamide

: 93493-66-4
N-(6-Chloro-4-formyl-3-pyridinyl)-2,2-dimethylpropanamide

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; N-methyl-acetamide; water; tert.-butyl lithium; isopropyl alcohol;

Reference yield:

: 5350-93-6
6-Chloro-pyridin-3-ylamine

: 93493-66-4
N-(6-Chloro-4-formyl-3-pyridinyl)-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

2: 1) tert-butyllithium / 1) THF, -78 deg C, 1.5 h; 2) THF, -78 deg C, 30 min

With tert.-butyl lithium; triethylamine; In dichloromethane;
DOI:10.1021/jo00302a049