(-)-(1S,2R,4S,6R)-2,4-bis(benzyloxy)-6-ethylaminocyclohexanol

Base Information

• Chemical Name: (-)-(1S,2R,4S,6R)-2,4-bis(benzyloxy)-6-ethylaminocyclohexanol
• CAS No.: 218915-52-7
• Molecular Formula: C₂₂H₂₉NO₃
• Molecular Weight: 355.477
• Mol file: 218915-52-7.mol

Synonyms:(-)-(1S,2R,4S,6R)-2,4-bis(benzyloxy)-6-ethylaminocyclohexanol

Chemical Property of (-)-(1S,2R,4S,6R)-2,4-bis(benzyloxy)-6-ethylaminocyclohexanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (-)-(1S,2R,4S,6R)-2,4-bis(benzyloxy)-6-ethylaminocyclohexanol

There total 1 articles about (-)-(1S,2R,4S,6R)-2,4-bis(benzyloxy)-6-ethylaminocyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethylamine (75-04-7,85404-22-4) + (+)-(1S,2R,4R,6R)-2,4-Bis(benzyloxy)-1,6-epoxycyclohexane (163878-18-0) → (-)-(1S,2R,4S,6R)-2,4-bis(benzyloxy)-6-ethylaminocyclohexanol (218915-52-7)

Guidance literature:

With ytterbium(III) triflate; In water; at 65 ℃; sealed tube;

DOI:10.1016/S0040-4039(98)01909-1

Reference yield: 78.0%

(-)-(1S,2R,4S,6R)-2,4-bis(benzyloxy)-6-ethylaminocyclohexanol (218915-52-7) → (1S,2R,4S,6R)-6-Ethylamino-cyclohexane-1,2,4-triol

Guidance literature:

With trimethylsilyl bromide; In chloroform; at 50 ℃; for 36h;

DOI:10.1039/b312808c

Reference yield: 69.0%

benzyl chloroformate (501-53-1,94274-21-2) + (-)-(1S,2R,4S,6R)-2,4-bis(benzyloxy)-6-ethylaminocyclohexanol (218915-52-7) → ((1R,2S,3R,5S)-3,5-Bis-benzyloxy-2-hydroxy-cyclohexyl)-ethyl-carbamic acid benzyl ester

Guidance literature:

With sodium hydroxide; at 0 ℃; for 2h;

DOI:10.1016/S0040-4039(98)01909-1

upstream raw materials:

ethylamine

(+)-(1S,2R,4R,6R)-2,4-Bis(benzyloxy)-1,6-epoxycyclohexane