7,10,13-tris(triethylsilyl)-2-debenzoyl-2-(2-allyloxybenzoyl)-10-deacetylbaccatin III

Base Information

Chemical Name:7,10,13-tris(triethylsilyl)-2-debenzoyl-2-(2-allyloxybenzoyl)-10-deacetylbaccatin III
CAS No.:237762-06-0
Molecular Formula:C₅₀H₈₂O₁₁Si₃
Molecular Weight:943.451
Hs Code.:

Synonyms:7,10,13-tris(triethylsilyl)-2-debenzoyl-2-(2-allyloxybenzoyl)-10-deacetylbaccatin III

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Chemical Property of 7,10,13-tris(triethylsilyl)-2-debenzoyl-2-(2-allyloxybenzoyl)-10-deacetylbaccatin III

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Technology Process of 7,10,13-tris(triethylsilyl)-2-debenzoyl-2-(2-allyloxybenzoyl)-10-deacetylbaccatin III

There total 5 articles about 7,10,13-tris(triethylsilyl)-2-debenzoyl-2-(2-allyloxybenzoyl)-10-deacetylbaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 2-(allyloxy)benzene magnesium bromide

: 237762-05-9
7-TES-2-debenzoylbaccatin-1,2-carbonate

: 237762-06-0
7,10,13-tris(triethylsilyl)-2-debenzoyl-2-(2-allyloxybenzoyl)-10-deacetylbaccatin III

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1021/ja000293w

Reference yield:

: 32981-86-5,172018-16-5
10-deacetylbaccatin III

: 237762-06-0
7,10,13-tris(triethylsilyl)-2-debenzoyl-2-(2-allyloxybenzoyl)-10-deacetylbaccatin III

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / imidazole / dimethylformamide / 47 h / 20 °C

2: 100 percent / Red-Al / tetrahydrofuran; toluene / 0.33 h / -10 °C

3: 97 percent / pyridine / 0 - 20 °C

4: 79 percent / tetrahydrofuran / 2 h / -78 °C

With pyridine; 1H-imidazole; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 1: silylation / 2: debenzoylation / 3: Condensation / 4: Ring cleavage;
DOI:10.1021/ja000293w

Reference yield:

: 994-30-9
triethylsilyl chloride

: 237762-06-0
7,10,13-tris(triethylsilyl)-2-debenzoyl-2-(2-allyloxybenzoyl)-10-deacetylbaccatin III

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / imidazole / dimethylformamide / 47 h / 20 °C

2: 100 percent / Red-Al / tetrahydrofuran; toluene / 0.33 h / -10 °C

3: 97 percent / pyridine / 0 - 20 °C

4: 79 percent / tetrahydrofuran / 2 h / -78 °C

With pyridine; 1H-imidazole; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 1: silylation / 2: debenzoylation / 3: Condensation / 4: Ring cleavage;
DOI:10.1021/ja000293w