tert-butyl benzyl-((R)-5-(9-(6-fluoropyridin-3-yl)-1-hydroxynonan-2-ylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

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Chemical Name:tert-butyl benzyl-((R)-5-(9-(6-fluoropyridin-3-yl)-1-hydroxynonan-2-ylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate
CAS No.:1092444-49-9
Molecular Formula:C₃₅H₄₇FN₆O₃
Molecular Weight:618.795
Hs Code.:

Synonyms:tert-butyl benzyl-((R)-5-(9-(6-fluoropyridin-3-yl)-1-hydroxynonan-2-ylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

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Chemical Property of tert-butyl benzyl-((R)-5-(9-(6-fluoropyridin-3-yl)-1-hydroxynonan-2-ylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

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Technology Process of tert-butyl benzyl-((R)-5-(9-(6-fluoropyridin-3-yl)-1-hydroxynonan-2-ylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

There total 17 articles about tert-butyl benzyl-((R)-5-(9-(6-fluoropyridin-3-yl)-1-hydroxynonan-2-ylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1092444-48-8
tert-butyl (R)-benzyl-{5-[1-(tert-butyl-dimethylsilyloxy)-9-(6-fluoropyridin-3-yl)-non-2-ylamino]-3-isopropyl-pyrazolo[1,5-a]pyrimidin-7-yl}carbamate

: 1092444-49-9
tert-butyl benzyl-((R)-5-(9-(6-fluoropyridin-3-yl)-1-hydroxynonan-2-ylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

Guidance literature:: tert-butyl (R)-benzyl-{5-[1-(tert-butyl-dimethylsilyloxy)-9-(6-fluoropyridin-3-yl)-non-2-ylamino]-3-isopropyl-pyrazolo[1,5-a]pyrimidin-7-yl}carbamate; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 771510-25-9
3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol

: 1092444-49-9
tert-butyl benzyl-((R)-5-(9-(6-fluoropyridin-3-yl)-1-hydroxynonan-2-ylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 16 h / Heating / reflux

2.1: ethanol / 3 h / Heating / reflux

3.1: dmap / tetrahydrofuran / 1.5 h / 20 °C

4.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 0.08 h

4.2: 13 h / 100 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With tetrabutyl ammonium fluoride; sodium t-butanolate; trichlorophosphate; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: 625-28-5
Isovaleronitrile

: 1092444-49-9
tert-butyl benzyl-((R)-5-(9-(6-fluoropyridin-3-yl)-1-hydroxynonan-2-ylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.17 h / -78 °C

1.2: 16.5 h / -78 - 20 °C

1.3: pH 3

2.1: acetic acid; hydrazine / ethanol / 16 h / Heating / reflux

3.1: sodium / ethanol / 16 h / Heating / reflux

3.2: pH 3

4.1: trichlorophosphate / 16 h / Heating / reflux

5.1: ethanol / 3 h / Heating / reflux

6.1: dmap / tetrahydrofuran / 1.5 h / 20 °C

7.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 0.08 h

7.2: 13 h / 100 °C

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With tetrabutyl ammonium fluoride; sodium; acetic acid; sodium t-butanolate; hydrazine; lithium diisopropyl amide; trichlorophosphate; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; toluene;