8-carbamoyl-6-chloro-7-(4-methoxyphenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride

Base Information

Chemical Name:8-carbamoyl-6-chloro-7-(4-methoxyphenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride
CAS No.:1352087-47-8
Molecular Formula:C₁₅H₁₆ClN₃O₂*ClH
Molecular Weight:342.225
Hs Code.:

Synonyms:8-carbamoyl-6-chloro-7-(4-methoxyphenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride

Suppliers and Price of 8-carbamoyl-6-chloro-7-(4-methoxyphenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8-carbamoyl-6-chloro-7-(4-methoxyphenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-carbamoyl-6-chloro-7-(4-methoxyphenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride

There total 6 articles about 8-carbamoyl-6-chloro-7-(4-methoxyphenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352087-46-7
tert-butyl 8-carbamoyl-6-chloro-7-(4-methoxy-phenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

: 1352087-47-8
8-carbamoyl-6-chloro-7-(4-methoxyphenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride

Guidance literature:: With chloro-trimethyl-silane; In methanol; for 19h;

Reference yield:

: 1352087-38-7
tert-butyl 8-cyano-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

: 1352087-47-8
8-carbamoyl-6-chloro-7-(4-methoxyphenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide; water; dihydrogen peroxide / methanol / 26 h / 55 °C

2: N-chloro-succinimide / dichloromethane / 6.66 h / -40 °C

3: N-Bromosuccinimide / ethyl acetate; Difluoromethane / 17 h / 0 - 20 °C

4: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 20 h / 100 °C / Inert atmosphere

5: chloro-trimethyl-silane / methanol / 19 h

With N-chloro-succinimide; N-Bromosuccinimide; chloro-trimethyl-silane; water; dihydrogen peroxide; caesium carbonate; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; Difluoromethane; dichloromethane; water; ethyl acetate; 4: Suzuki Coupling;

Reference yield:

: 1352087-39-8
tert-butyl 8-carbamoyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

: 1352087-47-8
8-carbamoyl-6-chloro-7-(4-methoxyphenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: N-chloro-succinimide / dichloromethane / 6.66 h / -40 °C

2: N-Bromosuccinimide / ethyl acetate; Difluoromethane / 17 h / 0 - 20 °C

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 20 h / 100 °C / Inert atmosphere

4: chloro-trimethyl-silane / methanol / 19 h

With N-chloro-succinimide; N-Bromosuccinimide; chloro-trimethyl-silane; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; Difluoromethane; dichloromethane; water; ethyl acetate; 3: Suzuki Coupling;