tert-butyl 8-carbamoyl-6-chloro-7-(4-methoxy-phenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

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Chemical Name:tert-butyl 8-carbamoyl-6-chloro-7-(4-methoxy-phenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate
CAS No.:1352087-46-7
Molecular Formula:C₂₀H₂₄ClN₃O₄
Molecular Weight:405.881
Hs Code.:

Synonyms:tert-butyl 8-carbamoyl-6-chloro-7-(4-methoxy-phenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

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Chemical Property of tert-butyl 8-carbamoyl-6-chloro-7-(4-methoxy-phenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

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Technology Process of tert-butyl 8-carbamoyl-6-chloro-7-(4-methoxy-phenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

There total 5 articles about tert-butyl 8-carbamoyl-6-chloro-7-(4-methoxy-phenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352087-41-2
tert-butyl 7-bromo-8-carbamoyl-6-chloro-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

: 5720-07-0
4-methoxyphenylboronic acid

: 1352087-46-7
tert-butyl 8-carbamoyl-6-chloro-7-(4-methoxy-phenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; at 100 ℃; for 20h; Inert atmosphere;

Reference yield:

: 1352087-38-7
tert-butyl 8-cyano-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

: 1352087-46-7
tert-butyl 8-carbamoyl-6-chloro-7-(4-methoxy-phenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; water; dihydrogen peroxide / methanol / 26 h / 55 °C

2: N-chloro-succinimide / dichloromethane / 6.66 h / -40 °C

3: N-Bromosuccinimide / ethyl acetate; Difluoromethane / 17 h / 0 - 20 °C

4: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 20 h / 100 °C / Inert atmosphere

With N-chloro-succinimide; N-Bromosuccinimide; water; dihydrogen peroxide; caesium carbonate; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; Difluoromethane; dichloromethane; water; ethyl acetate; 4: Suzuki Coupling;

Reference yield:

: 1352087-39-8
tert-butyl 8-carbamoyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

: 1352087-46-7
tert-butyl 8-carbamoyl-6-chloro-7-(4-methoxy-phenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-chloro-succinimide / dichloromethane / 6.66 h / -40 °C

2: N-Bromosuccinimide / ethyl acetate; Difluoromethane / 17 h / 0 - 20 °C

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 20 h / 100 °C / Inert atmosphere

With N-chloro-succinimide; N-Bromosuccinimide; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; Difluoromethane; dichloromethane; water; ethyl acetate; 3: Suzuki Coupling;