4,4,5,5-tetramethyl-2-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,3,2-dioxaborolane

Base Information

• Chemical Name: 4,4,5,5-tetramethyl-2-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,3,2-dioxaborolane
• CAS No.: 1367127-40-9
• Molecular Formula: C₁₉H₂₀BF₃O₃
• Molecular Weight: 364.172
• Mol file: 1367127-40-9.mol

Synonyms:4,4,5,5-tetramethyl-2-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,3,2-dioxaborolane

Chemical Property of 4,4,5,5-tetramethyl-2-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,3,2-dioxaborolane

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4,5,5-tetramethyl-2-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,3,2-dioxaborolane

There total 5 articles about 4,4,5,5-tetramethyl-2-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-bromo-4-[4-(trifluoromethyl)phenoxy]benzene (137736-26-6) + bis(pinacol)diborane (73183-34-3) → 4,4,5,5-tetramethyl-2-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,3,2-dioxaborolane (1367127-40-9)

Guidance literature:

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; In N,N-dimethyl-formamide; at 80 ℃; for 18h; Molecular sieve;

DOI:10.1021/jm500147k

Reference yield:

4-bromo-phenol (106-41-2) → 4,4,5,5-tetramethyl-2-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,3,2-dioxaborolane (1367127-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1: copper diacetate; N-ethyl-N,N-diisopropylamine; pyridine / dichloromethane / 12 h / 20 °C / Molecular sieve

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / N,N-dimethyl-formamide / 18 h / 80 °C / Molecular sieve

With pyridine; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; copper diacetate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm500147k

Reference yield:

4-trifluoromethylphenylboronic acid (128796-39-4) → 4,4,5,5-tetramethyl-2-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,3,2-dioxaborolane (1367127-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1: copper diacetate; N-ethyl-N,N-diisopropylamine; pyridine / dichloromethane / 12 h / 20 °C / Molecular sieve

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / N,N-dimethyl-formamide / 18 h / 80 °C / Molecular sieve

With pyridine; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; copper diacetate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm500147k

upstream raw materials:

4-bromo-phenol

1-bromo-4-[4-(trifluoromethyl)phenoxy]benzene

bis(pinacol)diborane

4-trifluoromethylphenylboronic acid

Downstream raw materials:

6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(4-(4(trifluoromethyl)phenoxy)phenyl)quinoline

6-chloro-7-methoxy-2-methyl-3-(4-(4-(trifluoromethyl)phenoxy)phenyl)quinolin-4(1H)-one

6-(2-carbamoyl-4-methylpiperazin-1-yl)-2-(4-(4-(trifluoromethyl)phenoxy)phenyl)pyrimidine-4-carboxamide

(S)-6-((1-amino-1-oxopropan-2-yl)amino)-2-(4-(4-(trifluoromethyl)phenoxy)phenyl)pyrimidine-4-carboxamide