(5S)-5-ethenyl-1-[4-iodo-2-(hydroxymethyl)phenyl]-2-pyrrolidinone

Base Information

• Chemical Name: (5S)-5-ethenyl-1-[4-iodo-2-(hydroxymethyl)phenyl]-2-pyrrolidinone
• CAS No.: 936114-93-1
• Molecular Formula: C₁₃H₁₄INO₂
• Molecular Weight: 343.164
• Mol file: 936114-93-1.mol

Synonyms:(5S)-5-ethenyl-1-[4-iodo-2-(hydroxymethyl)phenyl]-2-pyrrolidinone

Chemical Property of (5S)-5-ethenyl-1-[4-iodo-2-(hydroxymethyl)phenyl]-2-pyrrolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5S)-5-ethenyl-1-[4-iodo-2-(hydroxymethyl)phenyl]-2-pyrrolidinone

There total 14 articles about (5S)-5-ethenyl-1-[4-iodo-2-(hydroxymethyl)phenyl]-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 5-iodo-2-[(5S)-5-(ethenyl)-2-oxo-1-pyrrolidinyl]benzoate (936114-30-6) → (5S)-5-ethenyl-1-[4-iodo-2-(hydroxymethyl)phenyl]-2-pyrrolidinone (936114-93-1) + (2-amino-5-iodophenyl)methanol (53279-83-7)

Guidance literature:

With lithium borohydride; In methanol; at 0 ℃;

DOI:10.1016/j.tetlet.2007.02.008

Reference yield: 73.0%

C17H15IN2O5 → (5S)-5-ethenyl-1-[4-iodo-2-(hydroxymethyl)phenyl]-2-pyrrolidinone (936114-93-1)

Guidance literature:

With sodium tetrahydroborate; ethanol; In tetrahydrofuran; at 0 - 20 ℃; for 11h;

DOI:10.3987/COM-16-S(S)81

Reference yield: 70.0%

methyl 5-iodo-2-[(5S)-5-(ethenyl)-2-oxo-1-pyrrolidinyl]benzoate (936114-30-6) → (5S)-5-ethenyl-1-[4-iodo-2-(hydroxymethyl)phenyl]-2-pyrrolidinone (936114-93-1) + C13H18INO2

Guidance literature:

With methanol; lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃; for 20h; Inert atmosphere;

DOI:10.3987/COM-16-S(S)81

upstream raw materials:

methyl 5-iodo-2-[(5S)-5-(ethenyl)-2-oxo-1-pyrrolidinyl]benzoate

methyl 5-iodo-2-[(5S)-5-(hydroxyethyl)-2-oxo-1-pyrrolidinyl]benzoate

methyl 5-amino-2-[(5S)-5-{[(tert-butyl)dimethylsilyiloxyethyl]}-2-oxo-1-pyrrolidinyl]benzoate

methyl 5-nitro-2-[(5S)-5-{[(tert-butyl)dimethylsilyloxyethyl]}-2-oxo-1-pyrrolidinyl]benzoate

Downstream raw materials:

(5S)-5-ethenyl-1-[4-iodo-2-formylphenyl]-2-pyrrolidinol