ethyl 2-(4-((4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)acetate

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Chemical Name:ethyl 2-(4-((4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)acetate
CAS No.:1286278-66-7
Molecular Formula:C₁₈H₁₈N₈O₂
Molecular Weight:378.393
Hs Code.:

Synonyms:ethyl 2-(4-((4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)acetate

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Chemical Property of ethyl 2-(4-((4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)acetate

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Technology Process of ethyl 2-(4-((4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)acetate

There total 6 articles about ethyl 2-(4-((4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 637-81-0
ethyl-2-azidoacetate

: 1286278-45-2
C₁₄H₁₁N₅

: 1286278-66-7
ethyl 2-(4-((4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)acetate

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; In dimethyl sulfoxide; acetonitrile; at 20 ℃; for 3h; regioselective reaction;
DOI:10.1016/j.bmcl.2011.01.047

Reference yield:

: 42754-56-3
2-(methoxyphenylmethylene)malononitrile

: 1286278-66-7
ethyl 2-(4-((4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrochloride; triethylamine

2: 24 h / 180 °C

3: sodium carbonate / acetone; toluene / 24 h / 20 °C

4: copper(II) sulfate; sodium L-ascorbate / dimethyl sulfoxide; acetonitrile / 3 h / 20 °C

With hydrazine hydrochloride; sodium carbonate; copper(II) sulfate; sodium L-ascorbate; triethylamine; In dimethyl sulfoxide; acetone; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2011.01.047

Reference yield:

: 5515-36-6
α-cyano-β-hydroxycinnamonitrile

: 1286278-66-7
ethyl 2-(4-((4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / 1,4-dioxane

2: hydrazine hydrochloride; triethylamine

3: 24 h / 180 °C

4: sodium carbonate / acetone; toluene / 24 h / 20 °C

5: copper(II) sulfate; sodium L-ascorbate / dimethyl sulfoxide; acetonitrile / 3 h / 20 °C

With hydrazine hydrochloride; sodium hydrogencarbonate; sodium carbonate; copper(II) sulfate; sodium L-ascorbate; triethylamine; In 1,4-dioxane; dimethyl sulfoxide; acetone; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2011.01.047