6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid methyl ester

Base Information

• Chemical Name: 6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid methyl ester
• CAS No.: 133166-97-9
• Molecular Formula: C₁₈H₁₃Br₂FN₂O₄
• Molecular Weight: 500.119

Synonyms:6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid methyl ester

Chemical Property of 6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid methyl ester

Chemical Property:

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Technology Process of 6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid methyl ester

There total 2 articles about 6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.1%

phosgene (75-44-5) + N-<6-bromo-2-<<(4-bromo-2-fluorophenyl)methyl>amino>benzoyl>glycine methyl ester (133166-94-6) → 6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid methyl ester (133166-97-9)

Guidance literature:

In toluene; at 90 ℃; for 4h;

DOI:10.1021/jm00108a038

Reference yield:

5-bromoisatoic anhydride (4692-98-2) → 6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid methyl ester (133166-97-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH (80percent dispersion in mineral oil) / 1.) DMF, 2 h, 2.) 8 h

2: 87.6 percent / Et₃N / toluene / 4 h / 100 °C

3: 57.1 percent / toluene / 4 h / 90 °C

With sodium hydride; triethylamine; In toluene;

DOI:10.1021/jm00108a038

Reference yield: 67.5%

6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid methyl ester (133166-97-9) → 6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid (133166-46-8)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; for 0.5h;

DOI:10.1021/jm00108a038

upstream raw materials:

phosgene

N-<6-bromo-2-<<(4-bromo-2-fluorophenyl)methyl>amino>benzoyl>glycine methyl ester

5-bromoisatoic anhydride

Downstream raw materials:

6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid

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