(Z)-2-ACETAMIDO-3-(4-NITROPHENYL)ACRYLIC ACID

Base Information

• Chemical Name: (Z)-2-ACETAMIDO-3-(4-NITROPHENYL)ACRYLIC ACID
• CAS No.: 93341-45-8
• Molecular Formula: C11H10 N2 O5
• Molecular Weight: 250.211
• Hs Code.: 2924299090
• Mol file: 93341-45-8.mol

Synonyms:2-Propenoicacid, 2-(acetylamino)-3-(4-nitrophenyl)-, (Z)-;(2Z)-2-(Acetylamino)-3-(4-nitrophenyl)-2-propenoic acid

Chemical Property of (Z)-2-ACETAMIDO-3-(4-NITROPHENYL)ACRYLIC ACID

Chemical Property:

• PSA: 112.22000
• LogP: 2.07050

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (Z)-2-ACETAMIDO-3-(4-NITROPHENYL)ACRYLIC ACID

There total 5 articles about (Z)-2-ACETAMIDO-3-(4-NITROPHENYL)ACRYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(Z)-2-methyl-4-(4-nitrobenzylidene)oxazol-5(4H)-one (66949-13-1) → α-acetylamino-4-nitro-trans-cinnamic acid (93341-45-8)

Guidance literature:

With hydrogenchloride; at 100 ℃; for 0.5h;

DOI:10.1055/s-1992-26228

Reference yield:

(Z)-4-benzylidene-2-methyl-5(4H)-oxazolone (38879-46-8) → α-acetylamino-4-nitro-trans-cinnamic acid (93341-45-8)

Guidance literature:

With sulfuric acid; nitric acid;

DOI:10.1021/ja01149a054

Reference yield:

4-nitrobenzaldehdye (555-16-8) → α-acetylamino-4-nitro-trans-cinnamic acid (93341-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 0.17 h / Heating

2: aq. KOH / Heating

With potassium hydroxide; In benzene;

DOI:10.1055/s-1984-30859

upstream raw materials:

(Z)-2-methyl-4-(4-nitrobenzylidene)oxazol-5(4H)-one

(Z)-4-benzylidene-2-methyl-5(4H)-oxazolone

4-nitrobenzaldehdye

p-nitrobenzylideneaniline

Downstream raw materials:

N-acetyl-4-nitro-L-phenylalanine

N-acetyl-4-nitro-D-phenylalanine

3-(4-Nitro-phenyl)-2-oxo-N-((S)-1-phenyl-ethyl)-propionamide

2-hydroxy-3-(4-nitrophenyl)acrylic acid

Refernces

• 1、 Tripathy, Pradeep K.,Mukerjee, Arya K.. "A Fast Synthesis of 2-Acylamino-2-alkenoic Acids". . p. 418 - 422. Retrieved 2007/10/02.