3-Amino-1-benzyl-5-isobutyl-6-oxo-4-oxy-1,6-dihydro-pyrazine-2-carboxylic acid ethyl ester

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Chemical Name:3-Amino-1-benzyl-5-isobutyl-6-oxo-4-oxy-1,6-dihydro-pyrazine-2-carboxylic acid ethyl ester
CAS No.:135074-00-9
Molecular Formula:C₁₈H₂₃N₃O₄
Molecular Weight:345.398
Hs Code.:

Synonyms:3-Amino-1-benzyl-5-isobutyl-6-oxo-4-oxy-1,6-dihydro-pyrazine-2-carboxylic acid ethyl ester

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Chemical Property of 3-Amino-1-benzyl-5-isobutyl-6-oxo-4-oxy-1,6-dihydro-pyrazine-2-carboxylic acid ethyl ester

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Technology Process of 3-Amino-1-benzyl-5-isobutyl-6-oxo-4-oxy-1,6-dihydro-pyrazine-2-carboxylic acid ethyl ester

There total 4 articles about 3-Amino-1-benzyl-5-isobutyl-6-oxo-4-oxy-1,6-dihydro-pyrazine-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 100-39-0
benzyl bromide

: 131828-25-6
5-amino-6-(ethoxycarbonyl)-3-isobutyl-2(1H)-pyrazinone 4-oxide

: 135074-00-9
3-Amino-1-benzyl-5-isobutyl-6-oxo-4-oxy-1,6-dihydro-pyrazine-2-carboxylic acid ethyl ester

: 131828-26-7
5-amino-2-(benzyloxy)-6-(ethoxycarbonyl)-3-isobutylpyrazine 4-oxide

Guidance literature:: With potassium hydrogencarbonate; In N,N-dimethyl-formamide; for 16h; Ambient temperature;
DOI:10.1021/jo00016a012

Reference yield:

: 76617-78-2
2-(hydroxyimino)-4-methylpentanoic acid

: 135074-00-9
3-Amino-1-benzyl-5-isobutyl-6-oxo-4-oxy-1,6-dihydro-pyrazine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) N-hydroxysuccinimide, dicyclohexylcarbodiimide / 2) 4-(dimethylamino)pyridine / 1) dioxane, RT, 20 min, 2) 50 deg C, 14h

2: HOAc / 1 h / 70 °C

3: 13 percent / KHCO₃ / dimethylformamide / 16 h / Ambient temperature

With 1-hydroxy-pyrrolidine-2,5-dione; potassium hydrogencarbonate; acetic acid; dicyclohexyl-carbodiimide; dmap; In N,N-dimethyl-formamide;
DOI:10.1021/jo00016a012

Reference yield:

: 4502-00-5
sodium 4-methyl-2-oxovalerate

: 135074-00-9
3-Amino-1-benzyl-5-isobutyl-6-oxo-4-oxy-1,6-dihydro-pyrazine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NH₂OH*HCl / methanol

2: 1) N-hydroxysuccinimide, dicyclohexylcarbodiimide / 2) 4-(dimethylamino)pyridine / 1) dioxane, RT, 20 min, 2) 50 deg C, 14h

3: HOAc / 1 h / 70 °C

4: 13 percent / KHCO₃ / dimethylformamide / 16 h / Ambient temperature

With 1-hydroxy-pyrrolidine-2,5-dione; hydroxylamine hydrochloride; potassium hydrogencarbonate; acetic acid; dicyclohexyl-carbodiimide; dmap; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00016a012