4-[3-(4-methyl-piperazin-1-yl)-benzoylamino]-benzoic acid methyl ester

Base Information

• Chemical Name: 4-[3-(4-methyl-piperazin-1-yl)-benzoylamino]-benzoic acid methyl ester
• CAS No.: 709044-21-3
• Molecular Formula: C₂₀H₂₃N₃O₃
• Molecular Weight: 353.421
• Mol file: 709044-21-3.mol

Synonyms:4-[3-(4-methyl-piperazin-1-yl)-benzoylamino]-benzoic acid methyl ester

Chemical Property of 4-[3-(4-methyl-piperazin-1-yl)-benzoylamino]-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[3-(4-methyl-piperazin-1-yl)-benzoylamino]-benzoic acid methyl ester

There total 4 articles about 4-[3-(4-methyl-piperazin-1-yl)-benzoylamino]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 4-aminobenzoate hydrochloride (63450-84-0) + 3-(4-methyl-1-piperazinyl)benzoic acid (215309-01-6) → 4-[3-(4-methyl-piperazin-1-yl)-benzoylamino]-benzoic acid methyl ester (709044-21-3)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1016/j.ejmech.2003.12.008

Reference yield:

meta-aminobenzoic acid (99-05-8,159139-79-4) → 4-[3-(4-methyl-piperazin-1-yl)-benzoylamino]-benzoic acid methyl ester (709044-21-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 20 h / Heating

1.2: 21.7 percent / Na₂CO₃ / 12 h / Heating

2.1: aq. NaOH / methanol / 24 h / Heating

3.1: 90 percent / TBTU; diisopropylethylamine / dimethylformamide / 18 h / 20 °C

With sodium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2003.12.008

Reference yield:

nitrogen mustard (51-75-2) → 4-[3-(4-methyl-piperazin-1-yl)-benzoylamino]-benzoic acid methyl ester (709044-21-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 20 h / Heating

1.2: 21.7 percent / Na₂CO₃ / 12 h / Heating

2.1: aq. NaOH / methanol / 24 h / Heating

3.1: 90 percent / TBTU; diisopropylethylamine / dimethylformamide / 18 h / 20 °C

With sodium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2003.12.008

upstream raw materials:

methyl 4-aminobenzoate hydrochloride

3-(4-methyl-1-piperazinyl)benzoic acid

meta-aminobenzoic acid

nitrogen mustard