H₂N-Orn(Cbz)-Oxz(Ser)-Ala-Oxz(Ser)-OH

Base Information

Chemical Name:H₂N-Orn(Cbz)-Oxz(Ser)-Ala-Oxz(Ser)-OH
CAS No.:1308730-92-8
Molecular Formula:C₂₂H₂₅N₅O₇
Molecular Weight:471.47
Hs Code.:

H<sub>2</sub>N-Orn(Cbz)-Oxz(Ser)-Ala-Oxz(Ser)-OH

Synonyms:H₂N-Orn(Cbz)-Oxz(Ser)-Ala-Oxz(Ser)-OH

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Chemical Property of H₂N-Orn(Cbz)-Oxz(Ser)-Ala-Oxz(Ser)-OH

Chemical Property:

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Technology Process of H₂N-Orn(Cbz)-Oxz(Ser)-Ala-Oxz(Ser)-OH

There total 8 articles about H₂N-Orn(Cbz)-Oxz(Ser)-Ala-Oxz(Ser)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1308730-95-1
Fmoc-Orn(Cbz)-Oxz(Ser)-Ala-Oxz(Ser)-OMe

: 1308730-92-8
H₂N-Orn(Cbz)-Oxz(Ser)-Ala-Oxz(Ser)-OH

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 5h;
DOI:10.1039/c0ob01072c

Reference yield:

: 1269428-59-2
Boc-Orn(Cbz)-Oxz(Ser)-OMe

: 1308730-92-8
H₂N-Orn(Cbz)-Oxz(Ser)-Ala-Oxz(Ser)-OH

Guidance literature:: Multi-step reaction with 5 steps

1: water; sodium hydroxide / methanol / 18 h / 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 4 h / 20 °C / Inert atmosphere

3: sodium carbonate / 1,4-dioxane; water / 0 - 20 °C

4: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 22 h / 20 °C / Inert atmosphere

5: water; sodium hydroxide / tetrahydrofuran; methanol / 5 h / 20 °C

With hydrogenchloride; water; sodium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c0ob01072c

Reference yield:

: 1269428-60-5
C₂₁H₂₇N₃O₇

: 1308730-92-8
H₂N-Orn(Cbz)-Oxz(Ser)-Ala-Oxz(Ser)-OH

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / 1,4-dioxane; dichloromethane / 4 h / 20 °C / Inert atmosphere

2: sodium carbonate / 1,4-dioxane; water / 0 - 20 °C

3: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 22 h / 20 °C / Inert atmosphere

4: water; sodium hydroxide / tetrahydrofuran; methanol / 5 h / 20 °C

With hydrogenchloride; water; sodium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c0ob01072c