4-oxo-3-(phenylsulfinyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine

Base Information

Chemical Name:4-oxo-3-(phenylsulfinyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine
CAS No.:145471-63-2
Molecular Formula:C₂₈H₂₄N₂O₄S₂
Molecular Weight:516.642
Hs Code.:

Synonyms:4-oxo-3-(phenylsulfinyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine

Suppliers and Price of 4-oxo-3-(phenylsulfinyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-oxo-3-(phenylsulfinyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-oxo-3-(phenylsulfinyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine

There total 7 articles about 4-oxo-3-(phenylsulfinyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 4-oxo-3-(phenylthio)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine

: 145471-63-2
4-oxo-3-(phenylsulfinyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;
DOI:10.1002/chem.201501912

Reference yield:

: 145471-62-1
4-oxo-3,3-bis(phenylthio)-12-(p-toluenesulfonyl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine

: 145471-63-2
4-oxo-3-(phenylsulfinyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine

Guidance literature:: With sodium periodate; In tetrahydrofuran; methanol; water; at 20 ℃; for 48h;
DOI:10.1016/S0040-4039(00)61005-5

Reference yield:

: 4942-85-2
1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-4-one

: 145471-63-2
4-oxo-3-(phenylsulfinyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) -78 deg C, 2.) -30 -> 0 deg C

2: 87 percent / 12 N NaOH / n-Bu₄N⁽¹⁺⁾*HSO₄^(1-)

3: NaIO₄ / tetrahydrofuran; methanol; H₂O / 48 h / 20 °C

With sodium hydroxide; sodium periodate; lithium diisopropyl amide; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; methanol; water;
DOI:10.1016/S0040-4039(00)61005-5