2-hydroxy-N-(2-(pyridin-2-yl)propan-2-yl)-4-(trifluoromethyl)benzamide

Base Information

Chemical Name:2-hydroxy-N-(2-(pyridin-2-yl)propan-2-yl)-4-(trifluoromethyl)benzamide
CAS No.:1620193-65-8
Molecular Formula:C₁₆H₁₅F₃N₂O₂
Molecular Weight:324.303
Hs Code.:

Synonyms:2-hydroxy-N-(2-(pyridin-2-yl)propan-2-yl)-4-(trifluoromethyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-hydroxy-N-(2-(pyridin-2-yl)propan-2-yl)-4-(trifluoromethyl)benzamide

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Technology Process of 2-hydroxy-N-(2-(pyridin-2-yl)propan-2-yl)-4-(trifluoromethyl)benzamide

There total 2 articles about 2-hydroxy-N-(2-(pyridin-2-yl)propan-2-yl)-4-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1620193-48-7
N-(2-(pyridin-2-yl)propan-2-yl)-4-(trifluoromethyl)benzamide

: 1620193-65-8
2-hydroxy-N-(2-(pyridin-2-yl)propan-2-yl)-4-(trifluoromethyl)benzamide

Guidance literature:: With copper diacetate; tetra-(n-butyl)ammonium iodide; silver carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h; Inert atmosphere; Schlenk technique;
DOI:10.1021/ol5016064

Reference yield:

: 455-24-3
4-trifluoromethylbenzoic acid

: 52568-28-2
2-(pyridin-2-yl)isopropyl amine

: 1620193-65-8
2-hydroxy-N-(2-(pyridin-2-yl)propan-2-yl)-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

2: copper diacetate; silver carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere; Schlenk technique

With copper diacetate; tetra-(n-butyl)ammonium iodide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; silver carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/ol5016064