3-[[5-cyano-2-(methylthio)-4-pyrimidinyl]amino]-benzoic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: 3-[[5-cyano-2-(methylthio)-4-pyrimidinyl]amino]-benzoic acid 1,1-dimethylethyl ester
• CAS No.: 892413-67-1
• Molecular Formula: C₁₇H₁₈N₄O₂S
• Molecular Weight: 342.422
• Mol file: 892413-67-1.mol

Synonyms:3-[[5-cyano-2-(methylthio)-4-pyrimidinyl]amino]-benzoic acid 1,1-dimethylethyl ester

Chemical Property of 3-[[5-cyano-2-(methylthio)-4-pyrimidinyl]amino]-benzoic acid 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-[[5-cyano-2-(methylthio)-4-pyrimidinyl]amino]-benzoic acid 1,1-dimethylethyl ester

There total 1 articles about 3-[[5-cyano-2-(methylthio)-4-pyrimidinyl]amino]-benzoic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

tert-butyl 3-aminobenzoate (92146-82-2) + 4-chloro-5-cyano-2-methylthiopyrimidine (33089-15-5) → 3-[[5-cyano-2-(methylthio)-4-pyrimidinyl]amino]-benzoic acid 1,1-dimethylethyl ester (892413-67-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; for 1h; Heating / reflux;

Reference yield:

[2-[[(3-aminophenyl)methyl]amino]-2-oxoethyl]-carbamic acid 1,1-dimethylethyl ester (262368-49-0) + 3-[[5-cyano-2-(methylthio)-4-pyrimidinyl]amino]-benzoic acid 1,1-dimethylethyl ester (892413-67-1) → 3-[[5-cyano-2-[[3-[[[[[(1,1-dimethylethoxy)carbonyl]amino]acetyl]amino]methyl]phenyl]amino]-4-pyrimidinyl]amino]-benzoic acid 1,1-dimethylethyl ester

Guidance literature:

3-[[5-cyano-2-(methylthio)-4-pyrimidinyl]amino]-benzoic acid 1,1-dimethylethyl ester; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 2h;

[2-[[(3-aminophenyl)methyl]amino]-2-oxoethyl]-carbamic acid 1,1-dimethylethyl ester; In dichloromethane; at 20 - 60 ℃; for 1h;

upstream raw materials:

tert-butyl 3-aminobenzoate

4-chloro-5-cyano-2-methylthiopyrimidine