(2-bromo-4-methylbenzyl)(cyclohex-2-enyl)carbamic acid tert-butyl ester

Base Information

Chemical Name:(2-bromo-4-methylbenzyl)(cyclohex-2-enyl)carbamic acid tert-butyl ester
CAS No.:1293324-10-3
Molecular Formula:C₁₉H₂₆BrNO₂
Molecular Weight:380.325
Hs Code.:

Synonyms:(2-bromo-4-methylbenzyl)(cyclohex-2-enyl)carbamic acid tert-butyl ester

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Chemical Property of (2-bromo-4-methylbenzyl)(cyclohex-2-enyl)carbamic acid tert-butyl ester

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Technology Process of (2-bromo-4-methylbenzyl)(cyclohex-2-enyl)carbamic acid tert-butyl ester

There total 5 articles about (2-bromo-4-methylbenzyl)(cyclohex-2-enyl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 2-bromo-4-methylbenzyl(tert-butyl)carboxamide

: 1521-51-3,113667-32-6
rac-3-bromocyclohexene

: 1293324-10-3
(2-bromo-4-methylbenzyl)(cyclohex-2-enyl)carbamic acid tert-butyl ester

Guidance literature:: 2-bromo-4-methylbenzyl(tert-butyl)carboxamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; Inert atmosphere;

rac-3-bromocyclohexene; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1039/c0ob00449a

Reference yield:

: 131002-03-4
4-methyl-2- bromobenzamide

: 1293324-10-3
(2-bromo-4-methylbenzyl)(cyclohex-2-enyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 3 h / Reflux; Inert atmosphere

2.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 0 - 40 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0.17 h / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

With aluminum (III) chloride; lithium aluminium tetrahydride; thionyl chloride; sodium hydride; triethylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c0ob00449a

Reference yield:

: 1293323-97-3
2-bromo-4-methylbenzylamine hydrochloride

: 1293324-10-3
(2-bromo-4-methylbenzyl)(cyclohex-2-enyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.17 h / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c0ob00449a