tetra-tert-butyl 4,4'-((2,2'-(2,2'-(((4-(4-sulfamoylphenoxy)butyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl))heptanedioate

Base Information

Chemical Name:tetra-tert-butyl 4,4'-((2,2'-(2,2'-(((4-(4-sulfamoylphenoxy)butyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl))heptanedioate
CAS No.:1417889-96-3
Molecular Formula:C₆₆H₁₀₆N₈O₁₇S
Molecular Weight:1315.68
Hs Code.:

tetra-tert-butyl 4,4'-((2,2'-(2,2'-(((4-(4-sulfamoylphenoxy)butyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl))heptanedioate

Synonyms:tetra-tert-butyl 4,4'-((2,2'-(2,2'-(((4-(4-sulfamoylphenoxy)butyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl))heptanedioate

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Chemical Property of tetra-tert-butyl 4,4'-((2,2'-(2,2'-(((4-(4-sulfamoylphenoxy)butyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl))heptanedioate

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Technology Process of tetra-tert-butyl 4,4'-((2,2'-(2,2'-(((4-(4-sulfamoylphenoxy)butyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl))heptanedioate

There total 3 articles about tetra-tert-butyl 4,4'-((2,2'-(2,2'-(((4-(4-sulfamoylphenoxy)butyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl))heptanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1446011-93-3
4-(4-sulfamoylphenoxy)butan-1-aminium2,2,2-trifluoroacetate

: 1417889-98-5
di-tert-butyl 4-(3-(tert-butoxy)-3-oxopropyl)-4-(2-(2-formyl-1H-imidazol-1-yl)acetamido)heptanedioate

: 1417889-96-3
tetra-tert-butyl 4,4'-((2,2'-(2,2'-(((4-(4-sulfamoylphenoxy)butyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl))heptanedioate

Guidance literature:: 4-(4-sulfamoylphenoxy)butan-1-aminium2,2,2-trifluoroacetate; di-tert-butyl 4-(3-(tert-butoxy)-3-oxopropyl)-4-(2-(2-formyl-1H-imidazol-1-yl)acetamido)heptanedioate; With acetic acid; In 1,2-dichloro-ethane; at 75 ℃; for 0.5h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm3015348

Reference yield:

: 136586-99-7
4-amino-4-(2-tert-butoxycarbonylethyl)heptanedioic acid di-tertbutyl ester

: 1417889-96-3
tetra-tert-butyl 4,4'-((2,2'-(2,2'-(((4-(4-sulfamoylphenoxy)butyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl))heptanedioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; potassium iodide / N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere

3.1: acetic acid / 1,2-dichloro-ethane / 0.5 h / 75 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

With acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 885518-91-2
di-tert-butyl 4-(2-bromoacetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate

: 1417889-96-3
tetra-tert-butyl 4,4'-((2,2'-(2,2'-(((4-(4-sulfamoylphenoxy)butyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl))heptanedioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; potassium iodide / N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere

2.1: acetic acid / 1,2-dichloro-ethane / 0.5 h / 75 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With acetic acid; N-ethyl-N,N-diisopropylamine; potassium iodide; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;