Technology Process of (4E)-8-(tert-butyldiphenylsilyloxy)-4-octen-1-ol
There total 9 articles about (4E)-8-(tert-butyldiphenylsilyloxy)-4-octen-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
dichloromethane; water;
at 0 - 25 ℃;
for 2h;
DOI:10.1016/S0040-4020(97)00780-1
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
diethyl ether;
at 0 - 20 ℃;
for 2h;
DOI:10.1016/j.tet.2012.08.043
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: NaH / tetrahydrofuran / 1 h / 0 °C
1.2: 95 percent / tetrabutylammonium iodide / tetrahydrofuran / 14 h / 25 °C
2.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C
2.2: tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / 15 h / 0 - 25 °C
3.1: 3.03 g / HCl; water / tetrahydrofuran / 1.5 h / 0 - 25 °C
4.1: LiAlH4 / bis-(2-methoxy-ethyl) ether; tetrahydrofuran / 15 h / 0 - 140 °C
5.1: 5.91 g / imidazole / dimethylformamide / 18 h / 0 - 25 °C
6.1: 94 percent / dichlorodicyanobenzoquinone / CH2Cl2; H2O / 2 h / 0 - 25 °C
With
1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; water; sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; hexane; dichloromethane; diethylene glycol dimethyl ether; water; N,N-dimethyl-formamide;
1.1: Metallation / 1.2: Etherification / 2.1: Metallation / 2.2: Alkylation / 3.1: Hydrolysis / 4.1: Reduction / 5.1: silylation / 6.1: Oxidation;
DOI:10.1016/S0040-4020(97)00780-1
