2-(4-bromo-2-fluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl acetate

Base Information

• Chemical Name: 2-(4-bromo-2-fluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl acetate
• CAS No.: 1426050-16-9
• Molecular Formula: C₂₁H₂₆BrFN₂O₄
• Molecular Weight: 469.351
• Mol file: 1426050-16-9.mol

Synonyms:2-(4-bromo-2-fluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl acetate

Chemical Property of 2-(4-bromo-2-fluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-bromo-2-fluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl acetate

There total 8 articles about 2-(4-bromo-2-fluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-bromo-2-(4-bromo-2-fluorophenyl)ethyl acetate (1426050-15-8) + 4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one hydrochloride (1375107-47-3) → 2-(4-bromo-2-fluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl acetate (1426050-16-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

2-(4-bromo-2-fluorophenyl)ethan-1-ol (193290-20-9) → 2-(4-bromo-2-fluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl acetate (1426050-16-9)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine; dmap / 20 °C

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 8 h / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With pyridine; dmap; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In tetrachloromethane; N,N-dimethyl-formamide;

Reference yield:

2-(4-bromo-2-fluoro-phenyl)acetic acid (114897-92-6) → 2-(4-bromo-2-fluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl acetate (1426050-16-9)

Guidance literature:

Multi-step reaction with 4 steps

1: borane-THF / 20 - 50 °C

2: pyridine; dmap / 20 °C

3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 8 h / 80 °C

4: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With pyridine; dmap; N-Bromosuccinimide; borane-THF; 2,2'-azobis(isobutyronitrile); potassium carbonate; In tetrachloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2-(4-bromo-2-fluorophenyl)ethan-1-ol

2-(4-bromo-2-fluoro-phenyl)acetic acid

4-bromo-2-fluorophenethyl acetate

1,1-dimethylethyl-4-{[(chloroacetyl)(cyclopropyl)amino]methyl}-4-hydroxy-1-piperidine carboxylate