5-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3-isoxazolecarboxylic acid methyl ester

Base Information

Chemical Name:5-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3-isoxazolecarboxylic acid methyl ester
CAS No.:1313396-25-6
Molecular Formula:C₂₄H₂₁F₄NO₃
Molecular Weight:447.429
Hs Code.:

Synonyms:5-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3-isoxazolecarboxylic acid methyl ester

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Chemical Property of 5-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3-isoxazolecarboxylic acid methyl ester

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Technology Process of 5-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3-isoxazolecarboxylic acid methyl ester

There total 3 articles about 5-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3-isoxazolecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1313396-23-4
4-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-2-[(phenylmethoxy)imino]-3-butynoic acid methyl ester

: 1313396-25-6
5-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3-isoxazolecarboxylic acid methyl ester

Guidance literature:: With silver tetrafluoroborate; phenol; In 1,4-dioxane; for 168h; Reflux;
DOI:10.1016/j.tet.2011.04.083

Reference yield:

: 1313396-24-5
4-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-2-oxo-3-butynoic acid methyl ester

: 1313396-25-6
5-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3-isoxazolecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; sodium sulfate / methanol / 2 h / 20 °C / Inert atmosphere

2: silver tetrafluoroborate; phenol / 1,4-dioxane / 168 h / Reflux

With pyridine; silver tetrafluoroborate; sodium sulfate; phenol; In 1,4-dioxane; methanol;
DOI:10.1016/j.tet.2011.04.083

Reference yield:

: 949147-39-1
C₂₁H₁₈F₄

: 1313396-25-6
5-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3-isoxazolecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; triethylamine / tetrahydrofuran / 15 h / 20 °C / Inert atmosphere

2: pyridine; sodium sulfate / methanol / 2 h / 20 °C / Inert atmosphere

3: silver tetrafluoroborate; phenol / 1,4-dioxane / 168 h / Reflux

With pyridine; copper(l) iodide; silver tetrafluoroborate; sodium sulfate; triethylamine; phenol; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1016/j.tet.2011.04.083