4-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-2-[(phenylmethoxy)imino]-3-butynoic acid methyl ester

Base Information

Chemical Name:4-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-2-[(phenylmethoxy)imino]-3-butynoic acid methyl ester
CAS No.:1313396-23-4
Molecular Formula:C₃₁H₂₇F₄NO₃
Molecular Weight:537.554
Hs Code.:

Synonyms:4-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-2-[(phenylmethoxy)imino]-3-butynoic acid methyl ester

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Chemical Property of 4-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-2-[(phenylmethoxy)imino]-3-butynoic acid methyl ester

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Technology Process of 4-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-2-[(phenylmethoxy)imino]-3-butynoic acid methyl ester

There total 2 articles about 4-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-2-[(phenylmethoxy)imino]-3-butynoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1313396-24-5
4-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-2-oxo-3-butynoic acid methyl ester

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 1313396-23-4
4-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-2-[(phenylmethoxy)imino]-3-butynoic acid methyl ester

Guidance literature:: With pyridine; sodium sulfate; In methanol; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2011.04.083

Reference yield:

: 949147-39-1
C₂₁H₁₈F₄

: 1313396-23-4
4-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-2-[(phenylmethoxy)imino]-3-butynoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; triethylamine / tetrahydrofuran / 15 h / 20 °C / Inert atmosphere

2: pyridine; sodium sulfate / methanol / 2 h / 20 °C / Inert atmosphere

With pyridine; copper(l) iodide; sodium sulfate; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1016/j.tet.2011.04.083