N-(tetrahydro-2H-thiopyran-4-yl)-4-[2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide

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Chemical Name:N-(tetrahydro-2H-thiopyran-4-yl)-4-[2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide
CAS No.:1187323-24-5
Molecular Formula:C₁₉H₁₈F₃N₃O₂S₂
Molecular Weight:441.498
Hs Code.:

Synonyms:N-(tetrahydro-2H-thiopyran-4-yl)-4-[2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide

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Chemical Property of N-(tetrahydro-2H-thiopyran-4-yl)-4-[2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide

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Technology Process of N-(tetrahydro-2H-thiopyran-4-yl)-4-[2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide

There total 8 articles about N-(tetrahydro-2H-thiopyran-4-yl)-4-[2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: [2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]boronic acid

: 1187323-34-7
4-bromo-H-(tetrahydro-2H-thiopyran-4-yl)benzenesulfonamide

: 1187323-24-5
N-(tetrahydro-2H-thiopyran-4-yl)-4-[2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide

Guidance literature:: With potassium phosphate; 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex; In 1,4-dioxane; water; at 120 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1014607-03-4
2-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine 7-oxide

: 1187323-24-5
N-(tetrahydro-2H-thiopyran-4-yl)-4-[2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanesulfonyl chloride / N,N-dimethyl-formamide / 50 - 70 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 20 °C / Heating; Inert atmosphere

2.2: 20 - 80 °C / Inert atmosphere

2.3: 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1.25 h / 20 °C / Inert atmosphere

3.2: 0.5 h / -78 °C / Inert atmosphere

4.1: potassium phosphate / 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex / 1,4-dioxane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

With hydrogenchloride; potassium phosphate; sodium hydride; methanesulfonyl chloride; 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1014613-16-1
4-chloro-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine

: 1187323-24-5
N-(tetrahydro-2H-thiopyran-4-yl)-4-[2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane / 20 °C / Heating; Inert atmosphere

1.2: 20 - 80 °C / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1.25 h / 20 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

3.1: potassium phosphate / 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex / 1,4-dioxane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

With hydrogenchloride; potassium phosphate; sodium hydride; 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex; In tetrahydrofuran; 1,4-dioxane; water; mineral oil;