4-Chloro-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine

Base Information

Chemical Name:4-Chloro-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
CAS No.:1014613-16-1
Molecular Formula:C8H4ClF3N2
Molecular Weight:220.581
Hs Code.:
Mol file:1014613-16-1.mol

Synonyms:4-chloro-2-(trifluoromethyl)-3h-imidazo[4,5-c]pyridine;1H-Imidazo[4,5-c]pyridine,4-chloro-2-(trifluoromethyl)-(9CI);3H-Imidazo[4,5-c]pyridine,4-chloro-2-(trifluoromethyl);

Suppliers and Price of 4-Chloro-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Ambeed
4-Chloro-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 98+%
250mg
$ 598.00

Ambeed
4-Chloro-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 98+%
100mg
$ 379.00

Ambeed
4-Chloro-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 98+%
50mg
$ 272.00

Ambeed
4-Chloro-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 98+%
1g
$ 1318.00

Abosyn
4-chloro-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 95%-98%
1g
$ 645.00

Total 7 raw suppliers

Chemical Property of 4-Chloro-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine

Chemical Property:

PSA：28.68000
LogP:3.23510

Purity/Quality:

98% ^*data from raw suppliers

4-Chloro-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 98+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Chloro-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine

There total 4 articles about 4-Chloro-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1014607-03-4
2-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine 7-oxide

: 1014613-16-1
4-chloro-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: 2-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine 7-oxide; With methanesulfonyl chloride; In N,N-dimethyl-formamide; at 50 - 70 ℃; for 2h;

With sodium hydroxide; In water;

Reference yield:

: 918514-78-0
2-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine

: 1014613-16-1
4-chloro-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane

2: methanesulfonyl chloride / N,N-dimethyl-formamide / 3 h / 50 °C

With methanesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 138343-75-6
tert-butyl (3-methylpyridin-2-yl)carbamate

: 1014613-16-1
4-chloro-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 1.75 h / -3 - 0 °C

1.2: 1 h / 2 - 20 °C

2.1: hydrogenchloride / tetrahydrofuran; cyclohexane; water / 2.5 h / 3 - 80 °C

3.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 4.5 h / 0 - 20 °C

4.1: methanesulfonyl chloride / N,N-dimethyl-formamide / 2 h / 50 - 70 °C

With hydrogenchloride; n-butyllithium; methanesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; cyclohexane; water; ethyl acetate; N,N-dimethyl-formamide;