4-CYANO-2-FLUORO-BIPHENYL

Base Information

• Chemical Name: 4-CYANO-2-FLUORO-BIPHENYL
• CAS No.: 93129-69-2
• Molecular Formula: C₁₃H₈FN
• Molecular Weight: 197.212
• Hs Code.: 2926909090
• Mol file: 93129-69-2.mol

Synonyms:4-CYANO-2-FLUORO-BIPHENYL;3-FLUORO-1,1-BIPHENYL-4-CARBONITRILE

Chemical Property of 4-CYANO-2-FLUORO-BIPHENYL

Chemical Property:

• Vapor Pressure: 0.000356mmHg at 25°C
• Refractive Index: 1.595
• Boiling Point: 318.7°C at 760 mmHg
• Flash Point: 158.8°C
• PSA: 23.79000
• Density: 1.19g/cm³
• LogP: 3.36438

Purity/Quality:

99%+ ^*data from raw suppliers

4-Cyano-2-fluoro-biphenyl 95+% ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CYANO-2-FLUORO-BIPHENYL

There total 5 articles about 4-CYANO-2-FLUORO-BIPHENYL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-bromo-3-fluoro-4-phenylbenzene (41604-19-7) + N-cyano-N-phenyl-p-toluenesulfonamide (55305-43-6) → 2-fluoro-[1,1′-biphenyl]-4-carbonitrile (93129-69-2)

Guidance literature:

1-bromo-3-fluoro-4-phenylbenzene; With magnesium; lithium chloride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

N-cyano-N-phenyl-p-toluenesulfonamide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201003388

Reference yield: 80.0%

5-fluoro-2-cyanobenzoic acid (518070-24-1) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 2-fluoro-[1,1′-biphenyl]-4-carbonitrile (93129-69-2)

Guidance literature:

With dipotassium peroxodisulfate; silver nitrate; In acetonitrile; at 120 ℃; for 24h; Glovebox; Schlenk technique; Sealed tube; Inert atmosphere;

DOI:10.1002/anie.201408630

Reference yield: 60.0%

3,4-Difluorobenzonitrile (64248-62-0) + benzonitrile (100-47-0) → 2-fluoro-[1,1′-biphenyl]-4-carbonitrile (93129-69-2)

Guidance literature:

benzonitrile; With ammonia; sodium;

3,4-Difluorobenzonitrile; at -33 ℃;

DOI:10.1021/acs.joc.8b02904

upstream raw materials:

1-bromo-3-fluoro-4-phenylbenzene

copper(I) cyanide

N-cyano-N-phenyl-p-toluenesulfonamide

5-fluoro-2-cyanobenzoic acid

Downstream raw materials:

(Z)-isopropyl 3-(3-(2-fluoro-[1,1']biphenyl-4-yl)-1H-1,2,4-triazol-1-yl)acrylate

{4-[3-(2-fluorobiphenyl-4-yl)-1,2,4-oxadiazol-5-yl]phenyl}methanol