1-OXO-2-PHENYL-1,2-DIHYDRO-4-ISOQUINOLINECARBOXYLIC ACID

Base Information

• Chemical Name: 1-OXO-2-PHENYL-1,2-DIHYDRO-4-ISOQUINOLINECARBOXYLIC ACID
• CAS No.: 78364-18-8
• Molecular Formula: C₁₆H₁₁NO₃
• Molecular Weight: 265.268
• Hs Code.: 2933499090
• Mol file: 78364-18-8.mol

Synonyms:1-oxo-2-phenyl-1,2-dihydroisoquinoline-4-carboxylic acid

Chemical Property of 1-OXO-2-PHENYL-1,2-DIHYDRO-4-ISOQUINOLINECARBOXYLIC ACID

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

1-Oxo-2-phenyl-1,2-dihydroisoquinoline-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 1-OXO-2-PHENYL-1,2-DIHYDRO-4-ISOQUINOLINECARBOXYLIC ACID

There total 9 articles about 1-OXO-2-PHENYL-1,2-DIHYDRO-4-ISOQUINOLINECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1,2-dihydro-1-oxo-4-isoquinolinecarboxylic acid (34014-51-2) + phenylboronic acid (98-80-6) → 1-oxo-2-phenyl-1,2-dihydroisoquinoline-4-carboxylic acid (78364-18-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Molecular sieve;

Reference yield:

homophthalic anhydride (703-59-3) → 1-oxo-2-phenyl-1,2-dihydroisoquinoline-4-carboxylic acid (78364-18-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) glacial acetic acid, 100 deg C, 30 min

2: 1) 1N NaOH / 1) dioxane, 1 h

With sodium hydroxide;

Reference yield:

Homophthalic acid (89-51-0) → 1-oxo-2-phenyl-1,2-dihydroisoquinoline-4-carboxylic acid (78364-18-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / acetic acid anhydride / 1 h / Heating

2: 88 percent / dioxane / 1 h

3: 1) 1N NaOH / 1) dioxane, 1 h

With sodium hydroxide; acetic anhydride; In 1,4-dioxane;

upstream raw materials:

4-[1-Phenylamino-meth-(Z)-ylidene]-isochroman-1,3-dione

Homophthalic acid

homophthalic anhydride

4-Methoxymethylen-3,4-dihydro-1H-2-benzopyran-1,3-dion

Downstream raw materials:

C₂HF₃O₂*C₂₂H₂₅N₃O₂S₂

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