2-chloro-4-(4-methoxyphenyl)-6-morpholinonicotinonitrile

Base Information

Chemical Name:2-chloro-4-(4-methoxyphenyl)-6-morpholinonicotinonitrile
CAS No.:66663-28-3
Molecular Formula:C₁₇H₁₆ClN₃O₂
Molecular Weight:329.786
Hs Code.:

Synonyms:2-chloro-4-(4-methoxyphenyl)-6-morpholinonicotinonitrile

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Chemical Property of 2-chloro-4-(4-methoxyphenyl)-6-morpholinonicotinonitrile

Chemical Property:

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Technology Process of 2-chloro-4-(4-methoxyphenyl)-6-morpholinonicotinonitrile

There total 5 articles about 2-chloro-4-(4-methoxyphenyl)-6-morpholinonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 2,6-dichloro-4-(4-methoxyphenyl)nicotinonitrile

: 66663-28-3
2-chloro-4-(4-methoxyphenyl)-6-morpholinonicotinonitrile

Guidance literature:: In methanol; at 0 - 25 ℃; regioselective reaction; Inert atmosphere;
DOI:10.3390/molecules200917275

Reference yield:

: 402503-12-2
2,6-dihydroxy-4-(4-methoxyphenyl)nicotinonitrile

: 66663-28-3
2-chloro-4-(4-methoxyphenyl)-6-morpholinonicotinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 140 °C

2: methanol / 0 - 25 °C / Inert atmosphere

With trichlorophosphate; In methanol;
DOI:10.3390/molecules200917275

Reference yield:

: 22027-50-5
methyl 3-(4-methoxybenzoyl)acetate

: 66663-28-3
2-chloro-4-(4-methoxyphenyl)-6-morpholinonicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / methanol / 1 h / Reflux

2: trichlorophosphate / 140 °C

3: methanol / 0 - 25 °C / Inert atmosphere

With potassium hydroxide; trichlorophosphate; In methanol; 1: |Guareschi-Thorpe Condensation;
DOI:10.3390/molecules200917275