diphenyl ((4R,5R)-4,5-diphenyl-2-thioxooxazolidin-4-yl)phosphonate

Base Information

• Chemical Name: diphenyl ((4R,5R)-4,5-diphenyl-2-thioxooxazolidin-4-yl)phosphonate
• CAS No.: 1584736-46-8
• Molecular Formula: C₂₇H₂₂NO₄PS
• Molecular Weight: 487.516
• Mol file: 1584736-46-8.mol

Synonyms:diphenyl ((4R,5R)-4,5-diphenyl-2-thioxooxazolidin-4-yl)phosphonate

Chemical Property of diphenyl ((4R,5R)-4,5-diphenyl-2-thioxooxazolidin-4-yl)phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diphenyl ((4R,5R)-4,5-diphenyl-2-thioxooxazolidin-4-yl)phosphonate

There total 24 articles about diphenyl ((4R,5R)-4,5-diphenyl-2-thioxooxazolidin-4-yl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

diphenyl (isothiocyanato(phenyl)methyl)phosphonate (1403781-79-2) + benzaldehyde (100-52-7) → diphenyl ((4R,5R)-4,5-diphenyl-2-thioxooxazolidin-4-yl)phosphonate (1584736-46-8)

Guidance literature:

With C₃₂H₂₈F₆N₄O₃; In Dimethyl ether; at 30 ℃; for 48h; Reagent/catalyst; Solvent;

DOI:10.1002/anie.201308514

Reference yield:

diphenyl (isothiocyanato(phenyl)methyl)phosphonate (1403781-79-2) + benzaldehyde (100-52-7) → diphenyl ((4R,5R)-4,5-diphenyl-2-thioxooxazolidin-4-yl)phosphonate (1584736-46-8) + diphenyl ((4S,5S)-4,5-diphenyl-2-thioxooxazolidin-4-yl)phosphonate

Guidance literature:

With 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-(dimethylamino)cyclohexyl]thiourea; In toluene; at 30 ℃; for 48h; Overall yield = 85%;

DOI:10.1002/anie.201308514

Reference yield:

diphenyl (isothiocyanato(phenyl)methyl)phosphonate (1403781-79-2) + benzaldehyde (100-52-7) → diphenyl ((4R,5R)-4,5-diphenyl-2-thioxooxazolidin-4-yl)phosphonate (1584736-46-8) + C27H22NO4PS

Guidance literature:

With 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-(dimethylamino)cyclohexyl]thiourea; In acetonitrile; at 30 ℃; for 96h; Overall yield = 89%;

DOI:10.1002/anie.201308514

upstream raw materials:

benzaldehyde

diphenyl (isothiocyanato(phenyl)methyl)phosphonate

hydrobenzamide

C₂₆H₂₂NO₃P

Downstream raw materials:

diphenyl ((4R,5R)-3-acetyl-2-oxo-4,5-diphenyloxazolidin-4-yl)phosphonate

diphenyl ((4R,5R)-2-oxo-4,5-diphenyloxazolidin-4-yl)phosphonate