67022-39-3

Basic information

• Product Name: Methotrexate γ-Methyl Ester
• Synonyms: Methotrexate Impurity H;Methotrexate EP Impurity H;Methotrexate Impurity 8(EP-H);Methotrexate-5-monomethyl ester;Methotrexate Related Compound H;Methotrexate USP Related Compound H;Methotrexate-Methyl Ester (TEA salt);Methotrexate γ-Methyl Ester (Impurity H);Methotrexate Impurity 8（Methotrexate EP Impurity H）;Methotrexate EP Impurity H（Amethopterin EP Impurity H）
• CAS NO: 67022-39-3
• Molecular Formula: C₂₁H₂₄N₈O₅
• Molecular Weight: 468.46586
• Product Categories: Aromatics, Chiral Reagents, Heterocycles, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 67022-39-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 170-174 °C
• Appearance: /
• Density: 1.459±0.06 g/cm3(Predicted)
• PKA: 3.43±0.10(Predicted)
• CAS DataBase Reference: Methotrexate γ-Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methotrexate γ-Methyl Ester(67022-39-3)
• EPA Substance Registry System: Methotrexate γ-Methyl Ester(67022-39-3)

Safety Data

• Hazardous Substances Data: 67022-39-3(Hazardous Substances Data)

Usage

Uses

Methotrexate γ-methyl ester is an impurity of Methotrexate (M260675), a folic acid antagonist. Used as a antineoplastic and antirheumatic.

Upstream product

• 34378-65-9 dimethyl N-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamate 
• 66891-86-9 benzyl (4-(chlorocarbonyl)phenyl)(methyl)carbamate 
• 79974-15-5 N-<4-<<(benzyloxy)carbonyl>methylamino>benzoyl>-L-glutamic acid γ-methyl ester 
• 2528-30-5 4-<<(benzyloxy)carbonyl>methylamino>benzoic acid 
• 1499-55-4 L-glutamic acid 5-methyl ester 
• 10541-83-0 N-methyl-p-aminobenzoic acid 
• 19741-14-1 4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid 
• 79640-72-5 L-glutamic acid 1-tert-butyl ester 5-methyl ester 
• 67-56-1 methanol 
• 59-05-2 N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid 
• 79648-88-7 α-tert-butyl γ-methyl N'-<4--N-methylamino>benzoyl>-L-glutamate 
• 52853-40-4 6-bromomethyl-2,4-diaminopteridine hydrobromide 
• 79974-19-9 N-<4-(methylamino)benzoyl>-L-glutamic acid γ-methyl ester 

Downstream Products

• 121788-84-9 (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-[2,2,2-trifluoro-eth-(E)-ylidene-hydrazinocarbonyl]-butyric acid 
• 121788-83-8 (S)-4-Azidocarbonyl-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyric acid 
• 203723-22-2 methotrexate α,γ-bis(methyl 2-aminotetradecanoate) 
• 79640-75-8 N'-<4--N-methylamino>benzoyl>-L-glutamic acid γ-hydrazide 

Relevant articles and documents

The use of Tris-lipidation to modify drug cytotoxicity in multidrug resistant cells expressing P-glycoprotein or MRP1

1. Increasing the lipophilicity is a strategy often used to improve a compound's cellular uptake and retention but this may also convert it into a substrate for an ATP-dependent transporter such as P-glycoprotein or the multidrug resistance-associated pro

Syntheses of α- and γ-substituted amides, peptides, and esters of methotrexate and their evaluation as inhibitors of folate metabolism

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