(R)-2-Methyl-3-{2-[4-(prop-2-ene-1-sulphonyl)phenylamino]-5-trifluoromethylpyrimidin-4-yl-oxy}butan-2-ol

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Chemical Name:(R)-2-Methyl-3-{2-[4-(prop-2-ene-1-sulphonyl)phenylamino]-5-trifluoromethylpyrimidin-4-yl-oxy}butan-2-ol
CAS No.:1224162-09-7
Molecular Formula:C₁₉H₂₂F₃N₃O₄S
Molecular Weight:445.463
Hs Code.:

Synonyms:(R)-2-Methyl-3-{2-[4-(prop-2-ene-1-sulphonyl)phenylamino]-5-trifluoromethylpyrimidin-4-yl-oxy}butan-2-ol

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Chemical Property of (R)-2-Methyl-3-{2-[4-(prop-2-ene-1-sulphonyl)phenylamino]-5-trifluoromethylpyrimidin-4-yl-oxy}butan-2-ol

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Technology Process of (R)-2-Methyl-3-{2-[4-(prop-2-ene-1-sulphonyl)phenylamino]-5-trifluoromethylpyrimidin-4-yl-oxy}butan-2-ol

There total 4 articles about (R)-2-Methyl-3-{2-[4-(prop-2-ene-1-sulphonyl)phenylamino]-5-trifluoromethylpyrimidin-4-yl-oxy}butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1223498-60-9
2-chloro-4-[(R)-1,2-dimethyl-2-(tetrahydropyran-2-yloxy)propoxy]-5-trifluoromethylpyrimidine

: 53870-35-2
4-(prop-2-ene-1-sulfonyl)-aniline

: 1224162-09-7
(R)-2-Methyl-3-{2-[4-(prop-2-ene-1-sulphonyl)phenylamino]-5-trifluoromethylpyrimidin-4-yl-oxy}butan-2-ol

Guidance literature:: In ethanol; at 70 ℃; for 10h;

Reference yield:

: 1223498-54-1
(R)-3-(2-chloro-5-iodo-pyrimidin-4-yloxy)-2-methyl-butan-2-ol

: 1224162-09-7
(R)-2-Methyl-3-{2-[4-(prop-2-ene-1-sulphonyl)phenylamino]-5-trifluoromethylpyrimidin-4-yl-oxy}butan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium p-toluenesulfonate / dichloromethane / 22 h / 20 °C

2: potassium fluoride; copper(l) iodide / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 2 h / 90 °C

3: ethanol / 10 h / 70 °C

With potassium fluoride; copper(l) iodide; pyridinium p-toluenesulfonate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane;

Reference yield:

: 53399-77-2
(2R)-3-methyl-2,3-butanediol

: 1224162-09-7
(R)-2-Methyl-3-{2-[4-(prop-2-ene-1-sulphonyl)phenylamino]-5-trifluoromethylpyrimidin-4-yl-oxy}butan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / diethyl ether; mineral oil / 0.22 h / 0 - 20 °C

1.2: 0 - 40 °C

2.1: pyridinium p-toluenesulfonate / dichloromethane / 22 h / 20 °C

3.1: potassium fluoride; copper(l) iodide / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 2 h / 90 °C

4.1: ethanol / 10 h / 70 °C

With potassium fluoride; copper(l) iodide; pyridinium p-toluenesulfonate; sodium hydride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; ethanol; dichloromethane; mineral oil;