α-chlorocyclohexanecarboxaldehyde

Base Information

• Chemical Name: α-chlorocyclohexanecarboxaldehyde
• CAS No.: 57741-11-4
• Molecular Formula: C₈H₁₃ClO
• Molecular Weight: 160.644
• Mol file: 57741-11-4.mol

Synonyms:α-chlorocyclohexanecarboxaldehyde

Chemical Property of α-chlorocyclohexanecarboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of α-chlorocyclohexanecarboxaldehyde

There total 3 articles about α-chlorocyclohexanecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexylacetaldehyde (5664-21-1) → α-chlorocyclohexanecarboxaldehyde (57741-11-4) + C8H12Cl2O

Guidance literature:

With N-chloro-succinimide; rac-Pro-OH; In dichloromethane; at 0 - 20 ℃; for 18.5h; Overall yield = 78 percent; Overall yield = 990 mg; Inert atmosphere;

DOI:10.1016/j.tet.2020.131763

Reference yield:

cyclohexylacetaldehyde (5664-21-1) → α-chlorocyclohexanecarboxaldehyde (57741-11-4)

Guidance literature:

With (2R,5S)-2-tert-butyl 3,5-dimethylimidazolidin-4-one trifluoroacetic acid salt; 2,2,3,4,5,6-hexachloro-cyclohexa-2,4-dien-1-one; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1021/acs.orglett.6b02699

Reference yield:

cyclohexylethan-1-ol (4442-79-9) → α-chlorocyclohexanecarboxaldehyde (57741-11-4)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; In dichloromethane; at 0 - 20 ℃; for 2.5h;

DOI:10.1021/jacs.7b07104

upstream raw materials:

cyclohexylacetaldehyde

cyclohexylethan-1-ol

Downstream raw materials:

(cyclohexyl)chloroacetic acid

(S)-2-cyclohexyl-2-chloro-1-ethanol