3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid

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Chemical Name:3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid
CAS No.:1429291-90-6
Molecular Formula:C₁₇H₁₈Cl₂N₂O₅
Molecular Weight:401.246
Hs Code.:

Synonyms:3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid

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Chemical Property of 3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid

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Technology Process of 3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid

There total 3 articles about 3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1429293-42-4
ethyl 3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate

: 1429291-90-6
3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.8b00138

Reference yield:

: 1429293-20-8
(Z)-N-(3-(3,4-dichlorophenyl)propyl)-2-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-ylidene)acetamide

: 1429291-90-6
3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 0.17 h / 60 °C / Inert atmosphere; Microwave irradiation

1.2: 0.33 h / 100 °C / Inert atmosphere; Microwave irradiation

2.1: lithium hydroxide / water; tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With lithium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1021/acsmedchemlett.8b00138

Reference yield:

: 39959-89-2
3-(3,4-dichlorophenyl)propan-1-amine hydrochloride

: 1429291-90-6
3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 16 h / 0 - 16 °C / Inert atmosphere

2.1: methanol / 0.17 h / 60 °C / Inert atmosphere; Microwave irradiation

2.2: 0.33 h / 100 °C / Inert atmosphere; Microwave irradiation

3.1: lithium hydroxide / water; tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.8b00138