ethyl 3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate

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Chemical Name:ethyl 3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate
CAS No.:1429293-42-4
Molecular Formula:C₁₉H₂₂Cl₂N₂O₅
Molecular Weight:429.3
Hs Code.:

Synonyms:ethyl 3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate

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Chemical Property of ethyl 3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate

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Technology Process of ethyl 3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate

There total 3 articles about ethyl 3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1429293-20-8
(Z)-N-(3-(3,4-dichlorophenyl)propyl)-2-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-ylidene)acetamide

: 4244-84-2
ethyl β-alaninate hydrochloride

: 1429293-42-4
ethyl 3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate

Guidance literature:: formaldehyd; ethyl β-alaninate hydrochloride; With N-ethyl-N,N-diisopropylamine; In methanol; at 60 ℃; for 0.0833333h; Microwave irradiation;

(Z)-N-(3-(3,4-dichlorophenyl)propyl)-2-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-ylidene)acetamide; In methanol; at 100 ℃; for 0.25h; Microwave irradiation;

Reference yield: 71.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 924-73-2
3-amino-propionic acid ethyl ester

: 1429293-20-8
(Z)-N-(3-(3,4-dichlorophenyl)propyl)-2-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-ylidene)acetamide

: 1429293-42-4
ethyl 3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate

Guidance literature:: formaldehyd; 3-amino-propionic acid ethyl ester; In methanol; at 60 ℃; for 0.166667h; Inert atmosphere; Microwave irradiation;

(Z)-N-(3-(3,4-dichlorophenyl)propyl)-2-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-ylidene)acetamide; In methanol; at 100 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/acsmedchemlett.8b00138

Reference yield:

: 39959-89-2
3-(3,4-dichlorophenyl)propan-1-amine hydrochloride

: 1429293-42-4
ethyl 3-(4-((3-(3,4-dichlorophenyl)propyl)carbamoyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 16 h / 0 - 16 °C / Inert atmosphere

2.1: methanol / 0.17 h / 60 °C / Inert atmosphere; Microwave irradiation

2.2: 0.33 h / 100 °C / Inert atmosphere; Microwave irradiation

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.8b00138