(S)-N-(1-cyclohexylethyl)-P,P-diphenylphosphinamide

Base Information

• Chemical Name: (S)-N-(1-cyclohexylethyl)-P,P-diphenylphosphinamide
• CAS No.: 106651-31-4
• Molecular Formula: C₂₀H₂₆NOP
• Molecular Weight: 327.406
• Mol file: 106651-31-4.mol

Synonyms:(S)-N-(1-cyclohexylethyl)-P,P-diphenylphosphinamide

Chemical Property of (S)-N-(1-cyclohexylethyl)-P,P-diphenylphosphinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(1-cyclohexylethyl)-P,P-diphenylphosphinamide

There total 4 articles about (S)-N-(1-cyclohexylethyl)-P,P-diphenylphosphinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-cyclohexyl-N-(diphenylphosphinyl)ethanimine (106651-23-4) → (S)-N-(1-cyclohexylethyl)-P,P-diphenylphosphinamide (106651-31-4) + (R)-N-(1-cyclohexylethyl)-P,P-diphenylphosphinamide (106651-32-5)

Guidance literature:

With potassium 9-O-(1,2:5,6-di-O-isopropylidene-α-D-glucofuranosyl)-9-boratabicyclo<3.3.1>nonane; In tetrahydrofuran; at -78 ℃; for 0.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00380a047

Reference yield:

N-[(1E)-1-cyclohexylethylidene]-P,P-diphenylphosphinic amide → (S)-N-(1-cyclohexylethyl)-P,P-diphenylphosphinamide (106651-31-4) + (R)-N-(1-cyclohexylethyl)-P,P-diphenylphosphinamide (106651-32-5)

Guidance literature:

With trimethylaluminum; (S)-[1,1']-binaphthalenyl-2,2'-diol; isopropyl alcohol; In toluene; at 60 ℃; for 20h; Title compound not separated from byproducts;

DOI:10.1021/ol060110w

Reference yield:

cyclohexyl methyl ketone oxime (52316-19-5) → (S)-N-(1-cyclohexylethyl)-P,P-diphenylphosphinamide (106651-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / toluene / 1 h / 20 °C

2: (S)-BINOL; AlMe₃; 2-propanol / toluene / 20 h / 60 °C

With trimethylaluminum; (S)-[1,1']-binaphthalenyl-2,2'-diol; triethylamine; isopropyl alcohol; In toluene; 2: Meerwein-Schmidt-Ponndorf-Verley reduction;

DOI:10.1021/ol060110w

upstream raw materials:

1-cyclohexyl-N-(diphenylphosphinyl)ethanimine

cyclohexyl methyl ketone oxime

chloro-diphenylphosphine