1-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-3-methylsulfanyl-propan-1-one

Base Information

Chemical Name:1-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-3-methylsulfanyl-propan-1-one
CAS No.:1143522-15-9
Molecular Formula:C₃₇H₄₅Cl₂N₅O₃S
Molecular Weight:710.768
Hs Code.:

1-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-3-methylsulfanyl-propan-1-one

Synonyms:1-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-3-methylsulfanyl-propan-1-one

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Chemical Property of 1-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-3-methylsulfanyl-propan-1-one

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Technology Process of 1-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-3-methylsulfanyl-propan-1-one

There total 9 articles about 1-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-3-methylsulfanyl-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 646-01-5
3-(methylsulfanyl)propionic acid

: 1143522-16-0
[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-piperazin-1-yl-methanone

: 1143522-15-9
1-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-3-methylsulfanyl-propan-1-one

Guidance literature:: 3-(methylsulfanyl)propionic acid; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.25h;

[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-piperazin-1-yl-methanone; In N,N-dimethyl-formamide; for 1h;

Reference yield:

: 134653-81-9
ethyl 6-tert-butyl-4-oxo-4H-pyran-3-carboxylate

: 1143522-15-9
1-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-3-methylsulfanyl-propan-1-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: ammonium acetate; acetic acid / ethanol; water / 0.5 h / 95 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: potassium hydroxide; water / ethanol / 1 h / 80 °C

4.1: thionyl chloride / 2 h / 70 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.83 h / -10 °C

6.1: trichlorophosphate / toluene / Heating / reflux

6.2: 0 °C

7.1: triethylamine / dichloromethane; toluene / 0.5 h / 0 °C

8.1: Resolution of racemate

9.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

10.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h

10.2: 1 h

With potassium hydroxide; thionyl chloride; ammonium acetate; water; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1143519-21-4
6-tert-butyl-4-ethoxy-nicotinic acid

: 1143522-15-9
1-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-3-methylsulfanyl-propan-1-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / 2 h / 70 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.83 h / -10 °C

3.1: trichlorophosphate / toluene / Heating / reflux

3.2: 0 °C

4.1: triethylamine / dichloromethane; toluene / 0.5 h / 0 °C

5.1: Resolution of racemate

6.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

7.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h

7.2: 1 h

With thionyl chloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;