[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-piperazin-1-yl-methanone

Base Information

Chemical Name:[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-piperazin-1-yl-methanone
CAS No.:1143522-16-0
Molecular Formula:C₃₃H₃₉Cl₂N₅O₂
Molecular Weight:608.611
Hs Code.:

Synonyms:[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-piperazin-1-yl-methanone

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Chemical Property of [(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-piperazin-1-yl-methanone

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Technology Process of [(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-piperazin-1-yl-methanone

There total 9 articles about [(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-piperazin-1-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-85-0
piperazine

: 1143519-95-2
(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-innidazole-1-carbonyl chloride

: 1143522-16-0
[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-piperazin-1-yl-methanone

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.5h; Product distribution / selectivity;

Reference yield:

: 134653-81-9
ethyl 6-tert-butyl-4-oxo-4H-pyran-3-carboxylate

: 1143522-16-0
[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-piperazin-1-yl-methanone

Guidance literature:: Multi-step reaction with 9 steps

1.1: ammonium acetate; acetic acid / ethanol; water / 0.5 h / 95 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: potassium hydroxide; water / ethanol / 1 h / 80 °C

4.1: thionyl chloride / 2 h / 70 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.83 h / -10 °C

6.1: trichlorophosphate / toluene / Heating / reflux

6.2: 0 °C

7.1: triethylamine / dichloromethane; toluene / 0.5 h / 0 °C

8.1: Resolution of racemate

9.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With potassium hydroxide; thionyl chloride; ammonium acetate; water; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1143519-21-4
6-tert-butyl-4-ethoxy-nicotinic acid

: 1143522-16-0
[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-piperazin-1-yl-methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 2 h / 70 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.83 h / -10 °C

3.1: trichlorophosphate / toluene / Heating / reflux

3.2: 0 °C

4.1: triethylamine / dichloromethane; toluene / 0.5 h / 0 °C

5.1: Resolution of racemate

6.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With thionyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; toluene;