ethyl 2-<2-(3,4-dimethoxyphenyl)ethylamino>-2-(2-bromo-4,5-dimethoxyphenyl)acetate

Base Information

• Chemical Name: ethyl 2-<2-(3,4-dimethoxyphenyl)ethylamino>-2-(2-bromo-4,5-dimethoxyphenyl)acetate
• CAS No.: 154535-00-9
• Molecular Formula: C₂₂H₂₈BrNO₆
• Molecular Weight: 482.371
• Mol file: 154535-00-9.mol

Synonyms:ethyl 2-<2-(3,4-dimethoxyphenyl)ethylamino>-2-(2-bromo-4,5-dimethoxyphenyl)acetate

Chemical Property of ethyl 2-<2-(3,4-dimethoxyphenyl)ethylamino>-2-(2-bromo-4,5-dimethoxyphenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-<2-(3,4-dimethoxyphenyl)ethylamino>-2-(2-bromo-4,5-dimethoxyphenyl)acetate

There total 3 articles about ethyl 2-<2-(3,4-dimethoxyphenyl)ethylamino>-2-(2-bromo-4,5-dimethoxyphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) + ethyl 2-bromo-2-(2-bromo-4,5-dimethoxyphenyl)acetate (154534-98-2) → ethyl 2-<2-(3,4-dimethoxyphenyl)ethylamino>-2-(2-bromo-4,5-dimethoxyphenyl)acetate (154535-00-9)

Guidance literature:

With triethylamine; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1002/jhet.5570300541

Reference yield:

ethyl (2-bromo-4,5-dimethoxyphenyl)acetate (91881-19-5) → ethyl 2-<2-(3,4-dimethoxyphenyl)ethylamino>-2-(2-bromo-4,5-dimethoxyphenyl)acetate (154535-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / N-bromosuccinimide, azobisisobutyronitrile / CCl₄ / 1 h / Heating

2: 95 percent / triethylamine / CH₂Cl₂ / 1 h / Ambient temperature

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); triethylamine; In tetrachloromethane; dichloromethane;

DOI:10.1002/jhet.5570300541

Reference yield:

ethyl 3,4-dimethoxyphenylacetate (18066-68-7) → ethyl 2-<2-(3,4-dimethoxyphenyl)ethylamino>-2-(2-bromo-4,5-dimethoxyphenyl)acetate (154535-00-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / N-bromosuccinimide, hydrobromic acid / CCl₄ / 0.83 h / 40 °C

2: 97 percent / N-bromosuccinimide, azobisisobutyronitrile / CCl₄ / 1 h / Heating

3: 95 percent / triethylamine / CH₂Cl₂ / 1 h / Ambient temperature

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydrogen bromide; triethylamine; In tetrachloromethane; dichloromethane;

DOI:10.1002/jhet.5570300541

upstream raw materials:

2-(3,4-dimethoxyphenyl)-ethylamine

ethyl 2-bromo-2-(2-bromo-4,5-dimethoxyphenyl)acetate

ethyl (2-bromo-4,5-dimethoxyphenyl)acetate

ethyl 3,4-dimethoxyphenylacetate

Downstream raw materials:

ethyl 2--2-(2-bromo-4,5-dimethoxyphenyl)acetate