5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC

Base Information

• Chemical Name: 5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC
• CAS No.: 92973-24-5
• Molecular Formula: C12H7 F3 O3
• Molecular Weight: 256.181
• Hs Code.: 2932190090
• Mol file: 92973-24-5.mol

Synonyms:5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC

Chemical Property of 5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC

Chemical Property:

• Vapor Pressure: 3.19E-06mmHg at 25°C
• Melting Point: 163-167 °C(lit.)
• Refractive Index: 1.511
• Boiling Point: 372.9°C at 760 mmHg
• Flash Point: 179.3°C
• PSA: 50.44000
• Density: 1.395g/cm³
• LogP: 3.66360

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-[2-(Trifluoromethyl)phenyl]-2-furoic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25-36/37/38-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-[2-(Trifluoromethyl)phenyl]-2-furoic Acid is a chemical reagent used in the preparation of novel TRPV1 antagonists. Also used in the preparation of potent inhibitors of FeII and MnII E, coli Methionine Aminopeptidase as antibacterial agents.

Technology Process of 5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC

There total 6 articles about 5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-[2-(trifluoromethyl)phenyl]furan-2-carboxylic acid methyl ester (773874-52-5) → 5-(2-(trifluoromethyl)phenyl)furan-2-carboxylic acid (92973-24-5)

Guidance literature:

With potassium hydroxide; In ethanol; for 0.5h; Reflux;

DOI:10.1134/S1070428009040125

Reference yield: 20.0%

2-furanoic acid (88-14-2) + 2-(trifluoromethyl)benzenamine (88-17-5) → 5-(2-(trifluoromethyl)phenyl)furan-2-carboxylic acid (92973-24-5)

Guidance literature:

2-(trifluoromethyl)benzenamine; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.333333h;

2-furanoic acid; With copper dichloride; In water; acetone; at 20 ℃; for 24h;

DOI:10.1002/cmdc.201200076

Reference yield:

5-(2-Trifluoromethyl-phenyl)-furan-2-carbaldehyde (94098-56-3) → 5-(2-(trifluoromethyl)phenyl)furan-2-carboxylic acid (92973-24-5)

Guidance literature:

With silver nitrate; sodium hydroxide; In ethanol; water; at 60 ℃; for 2h; Heating;

DOI:10.1021/acs.jmedchem.1c01810

upstream raw materials:

2-furanoic acid

2-(trifluoromethyl)benzenamine

5-[2-(trifluoromethyl)phenyl]furan-2-carboxylic acid methyl ester

2-(trifluoromethyl)phenylboronic acid

Downstream raw materials:

5-(2-Trifluoromethyl-phenyl)-furan-2-carbonyl chloride

{[1-Chloro-1-[5-(2-trifluoromethyl-phenyl)-furan-2-yl]-meth-(Z)-ylidene]-amino}-acetic acid ethyl ester

{[5-(2-Trifluoromethyl-phenyl)-furan-2-carbonyl]-amino}-acetic acid ethyl ester

{5-[5-(2-Trifluoromethyl-phenyl)-furan-2-yl]-tetrazol-1-yl}-acetic acid ethyl ester