5-[2-(trifluoromethyl)phenyl]furan-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 5-[2-(trifluoromethyl)phenyl]furan-2-carboxylic acid methyl ester
• CAS No.: 773874-52-5
• Molecular Formula: C₁₃H₉F₃O₃
• Molecular Weight: 270.208
• Mol file: 773874-52-5.mol

Synonyms:5-[2-(trifluoromethyl)phenyl]furan-2-carboxylic acid methyl ester

Chemical Property of 5-[2-(trifluoromethyl)phenyl]furan-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-[2-(trifluoromethyl)phenyl]furan-2-carboxylic acid methyl ester

There total 3 articles about 5-[2-(trifluoromethyl)phenyl]furan-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl 5-bromo-2-furoate (2527-99-3) + 2-(trifluoromethyl)phenylboronic acid (1423-27-4) → 5-[2-(trifluoromethyl)phenyl]furan-2-carboxylic acid methyl ester (773874-52-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; toluene; for 6h; Heating;

DOI:10.1021/jm0492305

Reference yield: 64.0%

2-furoic acid methyl ester (611-13-2) + o-trifluoromethylphenyl bromide (392-83-6) → 5-[2-(trifluoromethyl)phenyl]furan-2-carboxylic acid methyl ester (773874-52-5)

Guidance literature:

With potassium acetate; palladium diacetate; In N,N-dimethyl acetamide; at 130 ℃; for 20h; regioselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201101102

Reference yield:

→ 5-[2-(trifluoromethyl)phenyl]furan-2-carboxylic acid methyl ester (773874-52-5)

Guidance literature:

upstream raw materials:

methyl 5-bromo-2-furoate

2-(trifluoromethyl)phenylboronic acid

2-furoic acid methyl ester

o-trifluoromethylphenyl bromide

Downstream raw materials:

5-(2-(trifluoromethyl)phenyl)furan-2-carboxylic acid