4-dibutylamino-2-[(triisopropylsilanyl)-ethynyl]-benzaldehyde

Base Information

• Chemical Name: 4-dibutylamino-2-[(triisopropylsilanyl)-ethynyl]-benzaldehyde
• CAS No.: 547735-43-3
• Molecular Formula: C₂₆H₄₃NOSi
• Molecular Weight: 413.719
• Mol file: 547735-43-3.mol

Synonyms:4-dibutylamino-2-[(triisopropylsilanyl)-ethynyl]-benzaldehyde

Chemical Property of 4-dibutylamino-2-[(triisopropylsilanyl)-ethynyl]-benzaldehyde

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-dibutylamino-2-[(triisopropylsilanyl)-ethynyl]-benzaldehyde

There total 1 articles about 4-dibutylamino-2-[(triisopropylsilanyl)-ethynyl]-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + N,N-dibutyl-4-iodo-3-[(triisopropylsilyl)ethynyl]aniline (248276-94-0) → 4-dibutylamino-2-[(triisopropylsilanyl)-ethynyl]-benzaldehyde (547735-43-3)

Guidance literature:

N,N-dibutyl-4-iodo-3-[(triisopropylsilyl)ethynyl]aniline; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

N,N-dimethyl-formamide; In tetrahydrofuran; for 12h; Heating;

DOI:10.1021/ol0345576

Reference yield:

4-dibutylamino-2-[(triisopropylsilanyl)-ethynyl]-benzaldehyde (547735-43-3) → C64H88N2Si2 (547735-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / methanol / 48 h

2: 30 percent / 1,2,2,6,6-pentamethylpiperidine; CuI; Pd₂(dba)3 / tetrahydrofuran / 16 h

With 1,2,2,6,6-pentamethylpiperidine; copper(l) iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; potassium carbonate; In tetrahydrofuran; methanol; 2: Cadiot-Chodkiewicz cross-coupling;

DOI:10.1021/ol0345576

Reference yield:

dimethyl 1-(1-diazo-2-oxopropyl)phosphonate (90965-06-3) + 4-dibutylamino-2-[(triisopropylsilanyl)-ethynyl]-benzaldehyde (547735-43-3) → N,N-dibutyl-4-ethynyl-3-[(triisopropylsilyl)ethynyl]aniline (547735-44-4)

Guidance literature:

With potassium carbonate; In methanol; for 48h;

DOI:10.1021/ol0345576

upstream raw materials:

N,N-dimethyl-formamide

N,N-dibutyl-4-iodo-3-[(triisopropylsilyl)ethynyl]aniline

Downstream raw materials:

N,N-dibutyl-4-ethynyl-3-[(triisopropylsilyl)ethynyl]aniline

C₆₄H₈₈N₂Si₂