4-hydroxy-3-[(3,5-difluoro-6-(3-(1-methylimidazolin-2-yl)phenoxy)-4-(2-methoxy-4-ethoxycarbonylphenoxy)pyridin-2-yl)oxy]benzamidine

Base Information

Chemical Name:4-hydroxy-3-[(3,5-difluoro-6-(3-(1-methylimidazolin-2-yl)phenoxy)-4-(2-methoxy-4-ethoxycarbonylphenoxy)pyridin-2-yl)oxy]benzamidine
CAS No.:183305-36-4
Molecular Formula:C₃₂H₂₉F₂N₅O₇
Molecular Weight:633.608
Hs Code.:

Synonyms:4-hydroxy-3-[(3,5-difluoro-6-(3-(1-methylimidazolin-2-yl)phenoxy)-4-(2-methoxy-4-ethoxycarbonylphenoxy)pyridin-2-yl)oxy]benzamidine

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Chemical Property of 4-hydroxy-3-[(3,5-difluoro-6-(3-(1-methylimidazolin-2-yl)phenoxy)-4-(2-methoxy-4-ethoxycarbonylphenoxy)pyridin-2-yl)oxy]benzamidine

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Technology Process of 4-hydroxy-3-[(3,5-difluoro-6-(3-(1-methylimidazolin-2-yl)phenoxy)-4-(2-methoxy-4-ethoxycarbonylphenoxy)pyridin-2-yl)oxy]benzamidine

There total 8 articles about 4-hydroxy-3-[(3,5-difluoro-6-(3-(1-methylimidazolin-2-yl)phenoxy)-4-(2-methoxy-4-ethoxycarbonylphenoxy)pyridin-2-yl)oxy]benzamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-{2-(2-benzyloxy-5-carbamimidoyl-phenoxy)-3,5-difluoro-6-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)-phenoxy]-pyridin-4-yloxy}-3-methoxy-benzoic acid ethyl ester

: 183305-36-4
4-hydroxy-3-[(3,5-difluoro-6-(3-(1-methylimidazolin-2-yl)phenoxy)-4-(2-methoxy-4-ethoxycarbonylphenoxy)pyridin-2-yl)oxy]benzamidine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 3h; under 2844.31 Torr;
DOI:10.1016/S0968-0896(01)00338-8

Reference yield:

: 700-16-3
Pentafluoropyridine

: 183305-36-4
4-hydroxy-3-[(3,5-difluoro-6-(3-(1-methylimidazolin-2-yl)phenoxy)-4-(2-methoxy-4-ethoxycarbonylphenoxy)pyridin-2-yl)oxy]benzamidine

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / cesium carbonate / acetonitrile / 12 h

2: 86 percent / cesium carbonate / acetonitrile / 20 h / 20 - 35 °C

3: 84 percent / cesium carbonate / dimethylsulfoxide / 17 h / 20 - 35 °C

4: 1.55 g / HCl / ethanol / 15 h

5: NH₃ / ethanol / 1.5 h / 75 °C

6: H₂ / 10 percent Pd/C / ethanol / 3 h / 2844.31 Torr

With hydrogenchloride; ammonia; hydrogen; caesium carbonate; palladium on activated charcoal; In ethanol; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/S0968-0896(01)00338-8

Reference yield:

: 617-05-0
ethyl vanillate

: 183305-36-4
4-hydroxy-3-[(3,5-difluoro-6-(3-(1-methylimidazolin-2-yl)phenoxy)-4-(2-methoxy-4-ethoxycarbonylphenoxy)pyridin-2-yl)oxy]benzamidine

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / cesium carbonate / acetonitrile / 12 h

2: 86 percent / cesium carbonate / acetonitrile / 20 h / 20 - 35 °C

3: 84 percent / cesium carbonate / dimethylsulfoxide / 17 h / 20 - 35 °C

4: 1.55 g / HCl / ethanol / 15 h

5: NH₃ / ethanol / 1.5 h / 75 °C

6: H₂ / 10 percent Pd/C / ethanol / 3 h / 2844.31 Torr

With hydrogenchloride; ammonia; hydrogen; caesium carbonate; palladium on activated charcoal; In ethanol; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/S0968-0896(01)00338-8