4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5,6-trifluoropyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester

Base Information

• Chemical Name: 4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5,6-trifluoropyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester
• CAS No.: 426826-63-3
• Molecular Formula: C₂₉H₂₁F₃N₂O₆
• Molecular Weight: 550.491

Synonyms:4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5,6-trifluoropyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester

Chemical Property of 4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5,6-trifluoropyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5,6-trifluoropyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester

There total 3 articles about 4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5,6-trifluoropyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-hydroxy-4-(benzyloxy)benzonitrile (194985-94-9) + 4-(2,3,5,6-tetrafluoropyridin-4-yl)oxy-3-methoxybenzoic acid, ethyl ester (199784-56-0) → 4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5,6-trifluoropyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester (426826-63-3)

Guidance literature:

With caesium carbonate; In acetonitrile; at 20 - 35 ℃; for 20h;

DOI:10.1016/S0968-0896(01)00338-8

Reference yield:

Pentafluoropyridine (700-16-3) → 4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5,6-trifluoropyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester (426826-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / cesium carbonate / acetonitrile / 12 h

2: 86 percent / cesium carbonate / acetonitrile / 20 h / 20 - 35 °C

With caesium carbonate; In acetonitrile;

DOI:10.1016/S0968-0896(01)00338-8

Reference yield:

ethyl vanillate (617-05-0) → 4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5,6-trifluoropyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester (426826-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / cesium carbonate / acetonitrile / 12 h

2: 86 percent / cesium carbonate / acetonitrile / 20 h / 20 - 35 °C

With caesium carbonate; In acetonitrile;

DOI:10.1016/S0968-0896(01)00338-8

upstream raw materials:

3-hydroxy-4-(benzyloxy)benzonitrile

4-(2,3,5,6-tetrafluoropyridin-4-yl)oxy-3-methoxybenzoic acid, ethyl ester

Pentafluoropyridine

ethyl vanillate

Downstream raw materials:

4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5-difluoro-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]-pyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester

4-[(2-(3-aminophenoxy)-6-(5-cyano-2-phenylmethoxyphenoxy)-3,5-difluoropyridin-4-yl)oxy]-3-methoxybenzoic acid, ethyl ester

4-hydroxy-3-[(3,5-difluoro-6-(3-(1-methylimidazolin-2-yl)phenoxy)-4-(2-methoxy-4-ethoxycarbonylphenoxy)pyridin-2-yl)oxy]benzamidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 426826-63-3 4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5,6-trifluoropyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send